083 - Botox / Boosters / Magic Mushrooms

The Body of Evidence

What does the body of evidence say on the topic of Botox injections? Plus: we address the confusion over bivalent COVID-19 booster shots, and we look at a trial of magic mushrooms for alcohol use disorder!

Block 1:

(3:00) Botox: what it is and what botulism does to you

Block 2:

(9:00) Botox: how Botox works on wrinkles, a comparison between formulations, what can go wrong, why repeated injections are needed, and the non-cosmetic uses of the botulinum toxin

Block 3:

(23:08) Bivalent booster vaccines and the reactive, libertarian public health response

Block 4:

(36:01) Magic mushrooms for alcohol use disorder

* Jingle by Jillian Correia of Roctavio Canada

* Theme music: “Fall of the Ocean Queen“ by Joseph Hackl.

* Assistant researcher: Nicholas Koziris

To contribute to The Body of Evidence, go to our Patreon page at: http://www.patreon.com/thebodyofevidence/.

To make a one-time donation to our show, you can now use PayPal! https://www.paypal.com/donate?hosted_button_id=9QZET78JZWCZE

Patrons get a bonus show on Patreon called “Digressions”! Check it out!

References:

1) Our episode on sunscreen: https://bodyofevidence.ca/019-sunscreen-and-the-mmr-vaccine

2) The cosmetic benefit of botulinum toxin: https://doi.org/10.1067/mjd.2002.121356

3) Differences between formulations: https://doi.org/10.1046/j.1524-4725.2003.29017.x

4) The FDA’s black box warning for Botox: https://jamanetwork.com/journals/jama/article-abstract/184061

5) Antibody formation after Botox: https://doi.org/10.1002/mds.23254

6) Cochrane review of Botox for migraine: https://doi.org/10.1136/bmjopen-2018-027953

7) Cochrane review of Botox for cervical dystonia: https://doi.org/10.1002/14651858.CD003633.pub4

8) Botox for urgency urinary incontinence: https://www.nejm.org/doi/full/10.1056/nejmoa1208872#:~:text=In%20summary%2C%20we%20found%20that,improvements%20in%20quality%20of%20life

9) New clinical trial of psilocybin-assisted psychotherapy for alcohol use disorder: https://jamanetwork.com/journals/jamapsychiatry/fullarticle/2795625

Music Credits:

The following music was used for this media project:

Music: Main Theme (The Grand Score) by Alexander Nakarada

Free download: https://filmmusic.io/song/4960-main-theme-the-grand-score

License (CC BY 4.0): https://filmmusic.io/standard-license

Artist website: https://www.serpentsoundstudios.com/