110: Spinning Like Earth: Designing Low-Shear Bioreactors for Better Cell Culture with Olivier Detournay - Part 2

Smart Biotech Scientist | Master Bioprocess CMC Development, Biologics Manufacturing & Scale-up, Cell Culture Innovation

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Could Earth's gentle movements hold the key to scaling up cell therapy production? In this fascinating episode, cellular biologist and entrepreneur Olivier Detournay (CSO of Cellura) reveals how his groundbreaking bioreactor design, inspired by geophysics, is transforming difficult cell culture processes.

By mimicking natural planetary motions, his team at Celura has developed a low-shear stress bioreactor that elegantly solves common scale-up challenges.

Key takeaways for biotech professionals:

• Discover how reducing rotational speed in larger volumes (from 70 RPM at 150ml to just 4 RPM at 200L) enables seamless scale-up
• Learn why simplifying bioreactor design leads to better control over shear stress and mixing quality
• Explore how nature-inspired solutions could make cell therapy manufacturing more accessible and cost-effective

Whether you're working in process development or manufacturing, this episode offers invaluable insights into the future of bioprocessing.

Listen now to uncover how looking to nature might help solve your toughest scale-up challenges.

Connect with Olivier Detournay:

LinkedIn: https://www.linkedin.com/in/olivier-detournay-5b157417

Cellura: https://cellura.io

Next Steps:

Wondering how to develop cell and gene therapies with peace of mind? Schedule your free assessment to propel your success: https://bruehlmann-consulting.com/assessment

Develop biologics better, faster, at a fraction of the cost with our Fractional CTO/CSO services. Curious? Learn more at https://bruehlmann-consulting.com