Кращі подкасти про CMC (2025)

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158: How to Detect Endotoxins Without Bleeding a Single Horseshoe Crab with Anika Hoffmann - Part 2 16:25

3 дні тому16:25

16:25

In this concluding episode of our series on revolutionary endotoxin detection, we continue our conversation with Anika Hoffmann about transitioning from theory to practice in the quest for more reliable, sustainable testing methods. Anika is a postdoctoral researcher in analytical chemistry at HES-SO Valais-Wallis, Switzerland. Having established w…

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God Cares. His Mediator Proves It. (Exodus 1:1-2:25)

7 днів тому

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The LORD’s compassion for His people is seen in His provision of a Mediator through Whom He rescues His people from oppression and slavery.Mitch Kimbrell

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CMC Talks: Chat with Mark Gulley and Guests Professor David Hughes and Kayleigh Lovegrove 1:00:19

26 днів тому1:00:19

1:00:19

This week Will and Karen are delighted to be joined by Professor David Hughes, Emeritus Professor of Food Marketing at Imperial College London and also known as ‘Dr Food’ and Kayleigh Lovegrove current Devon YFC County Chairman. This episode will discuss global and UK food trends, food self-sufficiency and emerging trends with consumers especially …

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157: How to Detect Endotoxins Without Bleeding a Single Horseshoe Crab with Anika Hoffmann - Part 1 22:38

5 днів тому22:38

22:38

In biopharmaceutical manufacturing, endotoxins represent a silent but deadly threat – bacterial fragments capable of triggering severe immune responses at picogram levels, potentially leading to septic shock, organ failure, or even death in patients. In this eye-opening first episode, we speak with Anika Hoffmann, a postdoctoral researcher in analy…

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156: The Hidden Economics of Continuous Processing That Most Biotech Companies Overlook 25:45

10 днів тому25:45

25:45

The world of biologics manufacturing is undergoing a major transformation. Once dominated by traditional batch processes, the industry is now experiencing a marked shift toward continuous bioprocessing. But as companies contemplate this transition, two questions dominate strategic discussions: Will regulators accept continuous manufacturing? And, p…

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155: From Process Bottlenecks to Seamless Production: How Continuous Bioprocessing Changes Everything 24:09

12 днів тому24:09

24:09

In this episode of the Smart Biotech Scientist Podcast, host David Brühlmann dives into continuous bioprocessing - a major shift in biologics manufacturing that's turning traditional batch processes into streamlined, real-time operations. Imagine running your biologics process non-stop for 30 days, with smart monitoring and smaller, more efficient …

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You Shall Know that I Am the LORD (Exodus Overview)

14 днів тому

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The LORD’s glory is displayed to Egypt and Israel by salvation through judgment, a salvation that results in His glorious presence among His people—all of which foreshadows the Person and work of the Lord Jesus Christ.Mitch Kimbrell

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154: The Future of Bioprocessing: Industry 4.0, Digital Twins, and Continuous Manufacturing Strategies with Tiago Matos - Part 2 16:16

17 днів тому16:16

16:16

In this episode, Tiago Matos, Associate Principal Scientist/Associate Director in Bioprocess Drug Substance and Commercialization at Merck & Co., shares a critical insight: continuous manufacturing in biologics currently demands 2–3x more time and FTEs than traditional fed-batch approaches. This highlights both the complexity of the shift - and the…

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153: The Future of Bioprocessing: Industry 4.0, Digital Twins, and Continuous Manufacturing Strategies with Tiago Matos - Part 1 28:58

19 днів тому28:58

28:58

As the biotechnology sector races toward digital transformation, the buzz around Industry 4.0 - with its promise of interconnected systems, automation, and data-driven operations - has never been louder. But is the industry truly ready? In this episode, we speak with Tiago Matos, Associate Principal Scientist/Associate Director in Bioprocess Drug S…

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Humility: Boasting in Jesus Christ (2 Corinthians Wrap-Up)

21 день тому

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If we desire to walk humbly with our God and obtain eternal life, then we must resist the seduction of pride and boast only in Jesus Christ.Eric Abbey

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152: Is an Indian CDMO the Right Move for Your Biologics Pipeline? with Abdelaziz Toumi - Part 2 21:21

24 дні тому21:21

21:21

Is an Indian CDMO the right move for your biologics CMC development? Pulling back the curtain on what might be your next strategic manufacturing advantage, this episode reveals the hidden capabilities emerging from India that leading biotech companies are racing to access. As supply chain vulnerabilities continue to expose risks in traditional manu…

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151: Is an Indian CDMO the Right Move for Your Biologics Pipeline? with Abdelaziz Toumi - Part 1 26:57

26 днів тому26:57

26:57

Is an Indian CDMO the right move for your biologics pipeline? As Western biotech companies seek new strategic advantages, one question keeps surfacing: Is India truly becoming the next biotech manufacturing powerhouse? And what hidden capabilities are emerging that leading companies are racing to access? In this episode of the Smart Biotech Scienti…

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The Ultimate Biopsy (2 Corinthians 12:14-13:14)

28 днів тому

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If we’re to live eternally, the ultimate biopsy of our character taken at the end of the age must reveal consistent Christian practiceWes Pastor

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Books, Books, and More Books!

рік тому

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For Christians, what is the value of reading books other than the Bible? What are some books that most all Christians ought to read? What are some of the books that have most helped or influenced our two hosts?Mitch Kimbrell & Craig Combs

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150: How to Leverage AI in Media Development Without Sacrificing Process Understanding with Tom Fletcher - Part 2 24:04

рік тому24:04

24:04

As biotech labs rush to adopt AI tools for cell culture media development, a critical question emerges: Are we creating a generation of scientists who know which buttons to push but not why they're pushing them? The automation trap that once transformed laboratory workflows now threatens to fundamentally alter how we understand the complex dynamics…

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149: How to Leverage AI in Media Development Without Sacrificing Process Understanding with Tom Fletcher - Part 1 18:27

рік тому18:27

18:27

From closely-guarded secrets to complex chemical interactions, cell culture media development has transformed from an afterthought to a critical competitive advantage in modern bioprocessing. But as AI and automation revolutionize the field, are we at risk of gaining speed while losing understanding? In this eye-opening episode of the Smart Biotech…

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The Upside-down Path to Power (2 Corinthians 12:1-13)

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To be empowered for godliness by the all-powerful Savior, be content with what the world regards as weakness.Mitch Kimbrell

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148: Lab-Grown Blood: How Stem Cells Transform Transfusions with Ari Gargir - Part 2 16:17

рік тому16:17

16:17

In the wake of the COVID-19 pandemic, the fragility of global blood supply systems became undeniably clear. Recognizing the urgent need for a more reliable and universal solution, Ari Gargir and his team at RedC Biotech are leading an ambitious effort to transform blood supply as we know it. Their mission? To develop lab-grown red blood cells that …

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147: Lab-Grown Blood: How Stem Cells Transform Transfusions with Ari Gargir - Part 1 22:01

рік тому22:01

22:01

Blood is critical to global healthcare - vital for surgeries, trauma care, cancer treatment, and maternal health. Yet despite 120 million donations each year, a 100 million unit shortfall means nearly half the world’s needs go unmet. One person who understands this crisis firsthand is Ari Gargir, CEO & Founder of RedC Biotech. After surviving a par…

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Behold the Lamb Crushed and Crowned (Revelation 4:1-5:14)

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All creation praises the Lamb crushed on the cross and crowned in glory, and His people’s path to glory will look like His. Let’s follow and worship Him!Mitch Kimbrell

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Saved From Wrath (John 19:1-42)

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Good Friday ServiceWes Pastor

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Shared Glory Through Love (John 13:31-35)

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Maundy Thursday ServiceCraig Combs

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146: Beyond ELISA: The 10-Minute Immunoassay Enabling Real-Time Bioprocess Control with Bruno Oesch - Part 2 18:09

рік тому18:09

18:09

Stuck with outdated analytics while trying to develop cutting-edge therapies? Part 2 of our conversation with Bruno Oesch, CEO and founder of Elionova, reveals how biotech scientists can finally break free from incremental improvements and embrace the revolutionary immunoassay technology that's transforming bioprocessing workflows worldwide. For ye…

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145: Beyond ELISA: The 10-Minute Immunoassay Enabling Real-Time Bioprocess Control with Bruno Oesch - Part 1 27:19

рік тому27:19

27:19

Tired of waiting overnight for ELISA results? Serial entrepreneur Bruno Oesch reveals how his groundbreaking 10-minute immunoassay technology is eliminating the biggest bottleneck in bioprocessing workflows. From contributing to Nobel Prize-winning prion research to founding Prionics (the first commercial BSE test) and now revolutionizing immunoass…

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The Burden-Lifting Lamb (Exodus 12)

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God delivers His people from the burden of sin and guilt through the judgment of the Passover Lamb, so that they can enjoy & celebrate Him forever.Eric Abbey

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CMC Talks: Chat with Mark Gulley and Guests Andrew Power and Paul Harris 1:00:46

рік тому1:00:46

1:00:46

CMC Talks: Chat with CMC Managing Director, Mark Gulley and Guests Andrew Power, CMC Sales Director and Paul Harris, REAL Success. CMC Talks - It’s all about people! Andrew Power - Sales Director, Crediton Milling Company Paul Harris - Founding & Managing Director, Real Success This week on CMC Talks, we’re talking all things people – why they stay…

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144: The Future of Biotech: Making Biotherapeutics More Accessible Faster 12:55

рік тому12:55

12:55

Imagine a future where every patient can access life-saving therapies and sustainable, high-quality food is within everyone’s reach. In this episode of the Smart Biotech Scientist, David Brühlmann explores how innovative biotech developments are making this vision a reality. Here’s a sneak peek of the breakthroughs covered: AI-Powered Picoliter Sca…

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143: Bioprocess Breakthroughs: How Smart Bioprocessing Is Democratizing Life-Saving Treatments 15:32

рік тому15:32

15:32

In the rapidly evolving world of biotechnology, innovation is not just happening at the molecular level. Industry leaders are making groundbreaking advancements in bioprocessing - a crucial component in making life-saving therapies more accessible and affordable. The journey to affordable therapies starts with the production process itself. In this…

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142: How Microalgae Cuts Antibody Costs by 70% and Redefines Biomanufacturing with Muriel Bardor - Part 2 17:06

рік тому17:06

17:06

What if we could revolutionize biotechnology by slashing antibody production costs by 70%? In a world where traditional mammalian cell cultures struggle with scalability and cost-effectiveness, an unexpected hero emerges from the depths of our oceans - microalgae. The use of microalgae in biotechnology is not just a novelty but a necessity, given t…

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141: How Microalgae Cuts Antibody Costs by 70% and Redefines Biomanufacturing with Muriel Bardor - Part 1 25:15

рік тому25:15

25:15

The world of biologics manufacturing is about to be transformed by a breakthrough that slashes antibody production costs by 70%. This revolutionary approach leverages the untapped potential of microalgae to deliver a sustainable, cost-effective solution that could make life-saving therapeutics more accessible than ever before. Enter microalgae, the…

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140: Regulatory Secrets Revealed: Why Your CMC Strategy Could Make or Break Your Biotech Startup with Rivka Zaibel - Part 2 20:42

рік тому20:42

20:42

In this episode, we explore the important steps in preparing for regulatory meetings, address the dangers of cross-contamination in biotechnology facilities, and debunk common misconceptions that could derail your CMC development strategy. As the founder and president of ADRES - Advanced Regulatory Services Ltd., Rivka Zaibel brings over 36 years o…

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139: Regulatory Secrets Revealed: Why Your CMC Strategy Could Make or Break Your Biotech Startup with Rivka Zaibel - Part 1 25:21

рік тому25:21

25:21

In biotherapeutic drug development, the journey from discovery to clinic involves navigating a labyrinth of regulatory requirements and strategic considerations, particularly in Chemistry, Manufacturing, and Control (CMC). In this episode of the Smart Biotech Scientist, host David Brühlmann engaged with Rivka Zaibel, President and Founder of ADRES …

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138: Skip 90% of Bioreactor Runs: The In Silico Revolution in Bioprocess Development with Yossi Quint - Part 2 20:16

рік тому20:16

20:16

In the fast-evolving world of biotechnology, the pursuit of efficiency and faster development has never been more critical. The computational tools and models currently being integrated into bioprocessing present a groundbreaking approach that promises radical shifts in drug development timelines and capabilities. In the second part of our conversa…

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137: Skip 90% of Bioreactor Runs: The In Silico Revolution in Bioprocess Development with Yossi Quint - Part 1 21:55

рік тому21:55

21:55

The integration of AI into drug discovery has already led to groundbreaking advancements, uncovering patterns in vast datasets that were previously invisible to human researchers. Now, AI is set to revolutionize bioprocessing as well. In this episode of the Smart Biotech Scientist Podcast, Yossi Quint, founder and CEO of Ark, and David Brühlmann ex…

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136: 5 Roadblocks to Affordable Biologics (And How to Overcome Them) 13:28

рік тому13:28

13:28

Sickle cell disease affects thousands with severe daily pain. While FDA-approved gene therapies exist, their $2.2 million cost per treatment makes them largely inaccessible. In this episode of the Smart Biotech Scientist Podcast, David Brühlmann explores five key challenges facing the bioprocessing industry in making these therapies more accessible…

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135: Beyond Breakthroughs: Making Biotherapeutics Affordable for All 12:46

рік тому12:46

12:46

In a world of rapid advancements in medical science and biotechnology, bioprocessing is at the forefront of healthcare innovation. Yet, despite remarkable progress, life-saving biotherapeutics remain out of reach for much of the global population. A staggering 80% of patients worldwide lack access to the biotherapeutics they need. While bioprocessi…

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CMC Talks: Chat with CMC Director, Mark Gulley and Guests James Coleman & Barny Butterfield 1:19:02

рік тому1:19:02

1:19:02

CMC Talks - How To Run a Successful Business! Guest 1: James Coleman - Managing Director, Creedy Carver Barny Butterfield - Founder, Sandford Orchards This week on CMC Talks, we’re diving into the core values of business with two incredible guests - James Coleman, Managing Director of Creedy Carvers, and Barny Butterfield, Founder of Sandford Orcha…

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134: Seamless Seed Trains: Simplify Without Sacrificing Quality with François Carruzzo - Part 2 16:53

рік тому16:53

16:53

The biotechnology industry is on a transformative path. With emerging technologies and innovative ideas, bioprocessing professionals are poised to revolutionize how therapies are developed and delivered. In this episode of the Smart Biotech Scientist Podcast, host David Brühlmann continues his conversation with François Carruzzo, the CTO of Bioscib…

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133: Seamless Seed Trains: Simplify Without Sacrificing Quality with François Carruzzo - Part 1 22:30

рік тому22:30

22:30

Biologics manufacturing relies heavily on optimizing various stages, yet the seed train step - often overlooked - plays a critical role in determining overall efficiency. The seed train involves expanding cells from a small working cell bank to scales suitable for production bioreactors. Francois Carruzzo, Co-founder and CTO of Bioscibex, is rethin…

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132: Combining AI and Biomanufacturing for Sustainable, Cost-Effective Therapeutics with Reza Farahani - Part 2 14:57

рік тому14:57

14:57

Artificial Intelligence (AI) is transforming industries worldwide, and biotechnology is no exception. In bioprocess development, AI is proving to be a game-changer, accelerating workflows, optimizing processes, and driving innovation. On the Smart Biotech Scientist Podcast, Reza Farahani, founder and CEO of Catalyze AI, shares his insights on how A…

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131: Combining AI and Biomanufacturing for Sustainable, Cost-Effective Therapeutics with Reza Farahani - Part 1 26:55

рік тому26:55

26:55

The real-world applications of AI in biomanufacturing are transformative. From reducing drug development timelines to optimizing production yields, AI is making biomanufacturing more efficient and cost-effective. This, in turn, enhances global access to life-saving therapies. As AI continues to evolve, its potential to drive even greater innovation…

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130: Revolutionizing Cell Therapy Manufacturing: Reducing Costs to Reach More Patients with Jason Foster - Part 2 20:15

рік тому20:15

20:15

The intricacies of tech transfer and the challenges of scaling manufacturing processes are often underestimated in the biotechnology industry. Understanding these complexities is crucial for translating innovative scientific breakthroughs into commercially viable products. In the second part of the conversation with Jason Foster, CEO of Ori Biotech…

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129: Revolutionizing Cell Therapy Manufacturing: Reducing Costs to Reach More Patients with Jason Foster - Part 1 22:10

рік тому22:10

22:10

One of the most urgent challenges in modern medicine is making cell and gene therapies widely accessible. These therapies, while groundbreaking in their safety and efficacy, often fall short when it comes to reaching patients. The reasons are manifold—high manufacturing costs, logistical complexities, and inefficiencies in the production pipeline. …

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128: The 7 Hidden Innovation Habits That Top Biotech Scientists Use Daily - Part 2 17:42

рік тому17:42

17:42

The world of bioprocess development in biotechnology is evolving at an unprecedented pace, driven by the quest for breakthrough innovations. While new technologies play a significant role, what truly sets successful innovators apart are fundamental habits that foster an environment ripe for groundbreaking discoveries. In today's discussion, we'll d…

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CMC Talks: Chat with CMC Director, Mark Gulley and Guests Scott, Darren & Ben! 50:35

рік тому50:35

50:35

Episode 7 of CMC Talks Podcast - It’s all in the planning! Guest: Scott Brimilcombe, Operations Director Darren Hughes, Mill Manager Ben Wonnacott, Transport Coordinator Join our very own Scott, Darren, and Ben as they talk about the process of animal feed production, sharing their knowledge and experiences from their time at CMC. They discuss the …

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127: The 7 Hidden Innovation Habits That Top Biotech Scientists Use Daily - Part 1 15:53

рік тому15:53

15:53

In the fast-paced and highly regulated world of biotech development, maintaining an innovative spirit can sometimes feel like a Herculean task. Between optimizing cell culture processes and navigating strict regulatory requirements, it’s no wonder many scientists feel the weight of daily operations pressing down on their creativity. However, foster…

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Ep 31. Rock Exotica 59:10

рік тому59:10

59:10

On this episode of the CMC Podcast, CMC instructor Doug McElmury talks to Rock Thompson from Rock Exotica. Rock Thompson is one of the most innovative and prolific people in any discipline that involves life safety rope equipment. In this podcast, Rock tells the story of the humble beginnings of Rock Exotica and how it has grown into a brand known …

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126: How to Enhance Cell Engineering Using Mechanical Intracellular Delivery with Armon Sharei - Part 2 20:31

рік тому20:31

20:31

As biotechnology rapidly evolves, cell therapies are emerging as a groundbreaking frontier with the potential to transform medicine. In this episode of the Smart Biotech Scientist Podcast, host David Brühlmann speaks with Armon Sharei, founder and CEO of Portal Bio, about the complexities, challenges, and future of cell therapies. Cell therapies co…

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125: How to Enhance Cell Engineering Using Mechanical Intracellular Delivery with Armon Sharei - Part 1 21:35

рік тому21:35

21:35

Intracellular delivery is essential for advancing research and clinical applications, yet it presents unique challenges when working with different cell types and biomolecules. In a recent episode of the Smart Biotech Scientist podcast, David Brühlmann spoke with Armon Sharei, the founder and CEO of Portal Bio, about the future of cell therapy, the…

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124: Manufacturability: Why Most Protein Candidates Fail (And How to Pick Winners Early) with Susan Sharfstein - Part 2 17:32

рік тому17:32

17:32

In part two of our insightful conversation, Dr. Susan Sharfstein builds on our previous discussion of developability assessment to explore how AI is revolutionizing protein manufacturability predictions. As a Professor of Nanoscale Science and Engineering at the University of Albany, she shares groundbreaking insights from her collaboration with De…

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