Researching Children's Brain Tumors

Southwestern Vermont Health Care's Medical Matters Weekly

Season 2 | Episode 42 | October 19, 2022
Dr. Filbin is the co-director for Research for the Pediatric-Neurooncology Program at Dana-Farber Cancer Institute and Boston Children’s Hospital. She earned her doctoral degrees in biochemistry and molecular biology from the Medical University of Graz, Austria. After a pediatric residency at Boston Children’s Hospital, she completed a fellowship in pediatric hematology/oncology at the Dana-Farber/Boston Children’s Cancer and Blood Disorders Center. She joined the faculty at Dana-Farber/Boston Children's as a pediatric neuro-oncologist in July 2017. In addition to her role in the treatment of patients with brain tumors, her research focuses on establishing cellular networks of tumor dependencies in pediatric brain tumors with the goal of finding new targeted therapies.
The Filbin Lab at the Dana-Farber Cancer Institute studies pediatric brain tumors, particularly the lethal high-grade gliomas, including DIPG and malignant embryonal brain tumors that are in greatest need of therapeutic improvements. The team is especially interested in how the specific developmental and cellular contexts in which tumorigenic mutations arise shape the cellular hierarchy of the resulting tumors. They combine single-cell genetics and transcriptomics with gene editing, epigenetic, stem cell and pharmacologic methods to identify these cellular states, hierarchies and networks underlying tumorigenesis, with the goal of establishing new druggable targets.
For more on Dr. Filbin’s lab, visit https://filbinlab.dana-farber.org/. SVHC is grateful to the AYJ Fund for their role in connecting us with Dr. Filbin. Visit https://www.ayjfund.org/ for more information.
Underwriter: Mack Molding

Medical Matters Weekly features the innovative personalities who drive positive change within health care and related professions. The show addresses all aspects of creating and maintaining a healthy lifestyle for all, including food and nutrition, housing, diversity and inclusion, groundbreaking medical care, exercise, mental health, the environment, research, and government. The show is produced with cooperation from Catamount Access Television (CAT-TV). Viewers can see Medical Matters Weekly on Facebook at facebook.com/svmedicalcenter and facebook.com/CATTVBennington. The show is also available to view or download a podcast on www.svhealthcare.org/medicalmatters. Questions can be emailed to [e-mail].
Underwriter: Mack Molding