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Developing Immunotherapies Using Oncolytic Viruses to Change the Tumor Microenvironment with Dr. Paul Peter Tak Candel Therapeutics TRANSCRIPT
Manage episode 307373405 series 2949197
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Dr. Paul Peter Tak is the President and CEO of Candel Therapeutics which is focused on educating the immune system to recognize and kill tumor cells in patients with a solid tumor. Candel is developing immunotherapies using engineered oncolytic viruses for prostate cancer, brain cancer, lung cancer, pancreatic cancer, and eye cancer.
Paul Peter explains, "Viruses probably got a bad reputation during the pandemic, but you can actually use them to do something beneficial to a patient, and that's what we are doing. So, using molecular engineering, we change the viruses in such a way that they infect the tumor cells and that they induce cell death. They kill the tumor cells in a way that activates the patient's own immune system, which is basically a very natural way to fight cancer."
"So, at the same time, we change the so-called tumor microenvironment from a cold tumor, a tumor that is not very active in terms of immune activity, into a hot tumor where we activate a whole variety of immune cells. And that's an optimal way to immunize the patient against the patient's own variety of so-called cancer neoantigens, the molecules that are being recognized by the patient's immune system."
#CandelTherapeutics #Oncology #OncolyticVirus #Immunotherapy #LungCancer #ProstateCancer #BrainCancer #Glioma #PancreaticCancer #EyeCancer #Cancer
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