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Episode 33 - CAR-T and Chromothripsis | Multiple Myeloma Review with Dr Christian Bryant
Manage episode 462391658 series 3596833
Вміст надано Bloody Minded Crew. Весь вміст подкастів, включаючи епізоди, графіку та описи подкастів, завантажується та надається безпосередньо компанією Bloody Minded Crew або його партнером по платформі подкастів. Якщо ви вважаєте, що хтось використовує ваш захищений авторським правом твір без вашого дозволу, ви можете виконати процедуру, описану тут https://uk.player.fm/legal.
Myeloma beware, it's time to bring out the big guns. We are incredibly thankful to be joined by a peak predator of plasma cells, Dr. Christian Bryant. He is a consultant Haematologist at RPA in Sydney, has a PhD on the immunology of myeloma and is driven by a passion to improve the treatment and understanding of all things myeloma.
TIMESTAMPS
2:18 - Intro to Christian Bryant
3:05 - Why Haematology?
5:31 - Why (oh god why) myeloma?
7:28 - Heavy metal, heavy chains
9:28 - Chromothripsis - The Cause That Breaks The Camel's Back?
13:45 - In praise of plasma cells
18:38 - Genomics to risk-stratify precursor states - should we bother?
20:32 - Predicting response and high risk disease
21:43 - IMS Criteria - High Genomic Risk
28:22 - Response Kinetics - When are you nervous?
31:31 - Balancing maintenance Len vs. secondary malignancies
39:34 - Other agents for maintenance?
44:44 - CAR-T - A New Hope?
49:10 - T cell exhaustion
50:21 - What are the CAR-T target molecules for MM?
53:27 - Any hope for a cure?
57:35 - MRD Matters
Check out show notes, additional references and (sometimes) extra content at www.bloodyminded.com.au
Розділи
1. Episode 33 - CAR-T and Chromothripsis | Multiple Myeloma Review with Dr Christian Bryant (00:00:00)
2. Intro to Christian Bryant (00:02:18)
3. Why Haematology? (00:03:05)
4. Why (oh god why) myeloma? (00:05:31)
5. Heavy metal, heavy chains (00:07:28)
6. Chromothripsis - The Cause That Breaks The Camel's Back? (00:09:28)
7. In praise of plasma cells (00:13:45)
8. Genomics to risk-stratify precursor states - should we bother? (00:18:38)
9. Predicting response and high risk disease (00:20:32)
10. IMS Criteria - High Genomic Risk (00:21:43)
11. Response Kinetics - When are you nervous? (00:28:22)
12. Balancing maintenance Len vs. secondary malignancies (00:31:31)
13. Other agents for maintenance? (00:39:34)
14. CAR-T - A New Hope? (00:44:44)
15. T cell exhaustion (00:49:10)
16. What are the CAR-T target molecules for MM? (00:50:21)
17. Any hope for a cure? (00:53:27)
18. MRD Matters (00:57:35)
34 епізодів
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