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X-Health.show - meet the future of healthcare

Alex Jani: interviewing visionaries of healthcare innovation

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The X-Health.show brings to you brilliant minds behind programming living cells, tech that detects pre-term delivery in seconds, brain-computer interface or apps that employ AI to match you, your disease with the best treatment. For the eXtra Health of the future. You’ll meet visionaries from Switzerland who push the boundaries of healthcare. Engineers who teamed up with doctors, scientists turned CEOs, doctors programming AI-powered apps, researchers who abandoned university labs to improve ...
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Take a wild guess: how many years will you get back when you limit your screen time? Yes, I said: YEARS. Spoiler: more than you think. But my guest gives an exact number. Because in this episode, you’ll hear about a phone addiction – or “problematic phone use” if you prefer how to tell if you’re addicted to your phone how to break a phone addiction…
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80% of people who lost weight, kept that weight off after two years. But quite a few did not even start. Those who did, did not follow any particular diet. People are too individual to follow one diet. They did not count calories. People hate counting calories. They love healthspan. They love longevity. What science-backed solutions work? In this e…
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Cultured meat or cultivated meat, made from cells, is not science-fiction any more. It is pure science. Though I could not help but thinking about Nancy Kress science-fiction book Beggars and Choosers when preparing to this episode. She writes about a world in 2106 where the society is split into a ruling class of Donkeys, who have access to real f…
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If you've ever given up on something because you thought you didn’t have the predisposition, you should listen to this episode. From sports genomics to genetic-based training. Can genes predict sports performance? And injuries in athletes? What is the contribution of genes to sports performance? We're speaking percentages. Can some athletes be too …
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By helping pumping blood, Ventricular Assist Devices during end-stage heart failure can prolong life. They can be implanted instead of a heart transplant or while waiting for a heart transplant. They may, however, come with some unwanted side effects, such as infections of a wound that doesn’t heal. The reason is that a cable connecting the Ventric…
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This might be a tool that sports psychologists have dreamed of: a way to measure athletes’ mental training efficacy for boosting sports performance. You know, like when a runner runs slower today than the day before their coach has the data to compare. If that same runner puts less effort into their mental training, their sports psychologist would …
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We are speaking about the world where wheelchairs will not be needed after a spinal cord injury. There are 250 000-500 000 spinal cord injuries globally each year. “A bunch of crazy guys,” in the words of my guest, him included, wants the spinal cord to self-regenerate. He is sure that in the future, we won’t be even speaking about regenerating the…
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How do you design a psychedelic trip that is predictable and effective? That frees people from cocaine addiction Without the common current side effects of psychedelics Just imagine being free from an addiction in a few hours This is what researchers and my guest today are trying to accomplish You’ll hear how did psychedelic studies continue in Swi…
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There are people who believe that stopping aging will be possible. For now, we can already speak about slowing down aging or even reversing aging – as Bryan Johnson set off to accomplish waving his "Don't Die" slogan. In this episode, you’ll hear about is collagen good for you? vegan collagen precursor at what age the production of some coenzymes s…
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Fetal surgeons save the life of a fetus with a birth defect – or improve the outcomes after birth – operating while still in utero. In a woman’s womb. Unsolvable so far – a hole in an amniotic sac after the surgery which causes preterm births. But here is where bioengineers have stepped in to support the surgeons. In this episode, you’ll hear about…
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The pain in your mouth is so bad that you cannot even drink, let alone eat. What is horrifying is that 50-80% of cancer patients undergoing chemo or radiotherapy can experience it – oral mucositis. And there is no approved treatment. This is what you’ll hear in this episode how a cute-looking willowherb grown in the Swiss Alps is making its way fro…
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Do you know what is the % of cancer drug candidates that fail in human trials? Guess, and I bet you underestimated it. This is what we speak at the beginning of this episode and what my guest wants to change dramatically. You will also hear about: the % of patients that actually benefit from approved cancer drug therapies (spoiler: so so low) cance…
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Think: an insulin pen but for solid drugs. Like, you are sure how much you administer EACH time. Like, you do not split the tablet in 3 worrying if this is 1/3 or closer to 1/4. And if that matters. One study showed that 1 in 4 caregivers gave a dose that deviated by more than 40%. And more studies point to drug administering errors. In this X-Heal…
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How long are you willing to stay in psychotherapy? Or do you want to just get better? This is what Joy wanted. To get better – faster. As a bioinformatician, she worked with big data sets and could not accept that in her psychotherapy she depended on paperwork, as if it was still the 20th century. You’ll hear in this episode what is digital phenoty…
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Managing diabetes is complex enough, adding sports on top of it seems too much for many. But what if you had an app that would help? You’ll hear about the physiology of exercising with type 1 and type 2 diabetes what can go wrong hypoglycaemia and hiperglycaemia ketoacidosis tools to use to take control of the glucose level and do sports seriously,…
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If you are a person with diabetes, you already know that some drugs cannot be administered other than via injections. Today’s guest works on a solution for these medications to be taken from the inside of the cheek. You’ll hear: how different kinds of drugs are absorbed why some drugs, macromolecular drugs, such as the ones for diabetes, need to be…
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The small amount of brown fat can make you slim. Too much may kill you. We just don't know who has it and how much. But this may change with this test. You’ll hear about brown fat but also white fat and beige fat what happens when we have too much brown fat or too little a new contrast agent to see brown fat on a CT scan that allows targeted therap…
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He dropped his engineering job to run 5 Ironman triathlons in 5 countries for a cause. But he did not foresee he would gather so many scientists on the way that try to find a way to mitigate dementia You’ll hear what does it take to run an Ironman triathlon how his family coped with his father’s Alzheimer’s how he united several startups and resear…
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Can the Dark Genome have the answer to any disease? And if you are wondering, what is the dark genome, you are not alone. And it is absolutely fascinating. Some scientists believe that the dark matter of the genome – previously called junk genome – might have the answer to many, many diseases. With the potential to cure them completely. Today we ar…
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Haven’t heard about breathing rate tracking yet? Listen up. You won’t need much to improve running: just your headset and an app. In this episode, you’ll hear about training plans based on breathing teaching ML models to recognize breathing patterns huge breathing data sets and how will you be able to use them to improve running and your training e…
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Challenging an over 100-year-old histology technic that is prone to false negatives. In cancer diagnostics. My guest aims to take histopathology departments from the 20th century into the 21st century, where they belong. From slicing biopsy samples into 3D. From a manual preparation to a robotic one. Where all abnormalities will be pointed out and …
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Another silent killer on the X-Health.show: diabetic neuropathy. Undetected in too many instances. Slowly taking away the balance. Implementing pain. Starting at the feet and unstoppable, if not treated. In this episode, you’ll hear about diabetic neuropathy and diabetic neuropathic pain the millions of people it concerns why the current treatment …
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How one approaches the goal of replacing chemotherapy with a gentler process? Where does the “we can do it” start? How do you get to the point where your process shows no side effects in the pre-clinical phase, in animals? And when will clinical trials start – in patients? In this episode, you’ll hear about how are blood cells produced acute myeloi…
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A specific strain of bacteria might help prevent and even treat colorectal cancer. The studies in animals show potential in treating other cancers, too. You’ll hear about how many bacteria inhabit a human and how much do they weigh (I bet you underestimate their weight) what is a dysbiotic gut microbiome the gut microbiome and its influence on colo…
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Out of 16 000 livers donated in the US, 7 000 are discarded. 14 000 patients are on the waiting list for a transplant. What if we could recondition the 7 000? What if we could treat these livers outside of a human body and transplant to the patients that need them? You’ll hear what’s the ideal liver graft and why there’s a shortage of them how to k…
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What is your optimal breathing rhythm for relaxing? How to make sure it is exactly for you? How to sleep better with a sensor on your chest? Today you’ll hear about sleeping better by tracking your sleep breathing exercises for anxiety, stress, panic attacks HRV or heart rate variability and ECG in a T-shirt smart textiles a sensor that detects how…
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Take a plastic chip, a bunch of cells, add some real complex engineering and cellular biology science and you'll have a lung-on-a-chip that can breathe as if in a human body. You're ready to test drugs, as if on people, instead of mice on organs-on-chips. In this episode, you’ll hear about the biology of breathing, down to the cellular level, how t…
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You cannot underestimate the emotion when you can feel the warmth of someone’s hand in the hand you do not have. Or cold in the fingers you have not had for years. In this episode, you’ll hear about how people with an amputated hand, can feel the temperature in their phantom hand why you don’t really feel wet or can be tricked into feeling wet when…
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Imagine breathing into a small tube for a few minutes, then your breath aerosol is sent for a PCR analysis. Quick you'll have the result: bacteria or virus causing pneumonia and can have the right treatment prescribed. You’ll hear how tricky it is to detect bacteria and viruses in the breath why so many pneumonia cases are deadly what is an electro…
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If you suddenly slide into sepsis, there’s a 50% chance you’ll survive. Because it is so hard to detect it. Lab-on-Skin works to change it. And has the Mayo Clinic on their side. Today you’ll hear about continuous shock monitoring – to detect the earliest symptoms of sepsis how to assess sepsis nanotechnology, nanoelectronics, nanofluidics and the …
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When do you think you start aging? Age-related mitochondrial decline, one of the reasons for aging, starts in your 30s and 40s. Pretty early, huh? Is this a moment to think about longevity supplements? Today you’ll hear about longevity and healthy aging improving your healthspan from the cellular level mitophagy and how to amp it up the power of po…
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Older biological age is associated with higher mortality and various age-related diseases. What can you do if you know that you look older, feel older, are older biologically than the date of birth on your passport? What can you do with your test biological age? You’ll hear about longevity and healthspan chronological vs biological age what is an e…
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If you miss your glaucoma appointment in the UK, you could partially go blind while waiting for the next one. How about taking the test by yourself at home with a VR headset? You’ll hear about why banging into objects can be both glaucoma early symptoms, and late ones why many people don’t even realize they have glaucoma how glaucoma is diagnosed n…
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Instead of or before a genetic test – a blood smear analysis to detect blood cancers might soon be an option. What a human eye cannot see – also under a microscope, computer vision + AI can. You’ll hear about cancer diagnostics in highly specialized centers why is Next-Generation Sequencing so expensive how AI and computer vision can help bring per…
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You don't see your bones melting in a hot bath, so usually osteoporosis is diagnosed too late. 20% of people with an osteoporotic fracture will die within a year. 1 woman out of 2 will develop osteoporosis after menopause 1-2 men out of 5 will develop osteoporosis but more men die of the consequences of osteoporosis Now, this can change. You may ac…
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In your gut microbiome, there is a small family of bacteria that have a super important role to play: activate vitamin B6, regulate obesity, improve your mood, reduce anxiety and stress. You’ll hear about gut microbiome balance, how to achieve it, and how to kill it this small family of gut bacteria, namely Bifidobacteria the role of Bifidobacteria…
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To search for a possibly life-saving ground-breaking treatment for a cancer patient that is available only in clinical trials it takes: personal connections your oncologist network long hours frustration and luck. Ancora.ai wants to change it. Make clinical trials and innovative treatments more accessible for patients. Accelerate the search for pat…
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A drug that works for a mouse might not work for a human. How about testing drugs for inflammatory diseases – and cosmetics – on human organoids? You’ll hear what are human vascular organoids and how to grow human cells also about the mechanisms of inflammation and the ability to see where drugs can block it arthritis and other chronic inflammatory…
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If you heard about miraculous CAR-T cell therapies that cure cancer in one go, my guest today works on something one step further: immunotherapies that are manufactured from healthy donor cells. That means a thousand cancer patients may receive in the future a life-saving shot manufactured ahead and administered when needed. You may expect a fascin…
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While growing bone organoids, it is apparently important to take bone cells to the gym three times a week. Or – apply mechanical loading, if you want to use more precise language. You’ll hear about mechanical properties of the human bone how to grow bone organoids and what can you test on them osteogenesis imperfecta called glass bones osteosarcoma…
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A new wearable is coming to the market in 2024: a smaller ring to track your sleep, stress, calories burnt, and other vitals and activities. Already pre-ordered by over 7000 people. You’ll hear about a smart ring that is smaller than other rings and what fits inside what can you track with it the differences between various wearables: smartwatches,…
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Could a robot perform trachea intubation? How about letting AI guide clinicians and paramedics in inserting the tube into people's airways? You’ll hear what is tracheal intubation and why it is far from putting a straw in a bottle what can go tragically wrong how long do anaestesiologists perfect the skill and how much less some other specializatio…
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Have a glimpse into the future of cancer treatment where an army of your own tiny soldiers fiercely combats the most stubborn cancers, even at late stage. They’re called T cells. My today’s guest has worked on immunotherapies that arm T cells, patient’s own white blood cells with weapons agains tumors to infuse them back to the patient’s body. Whet…
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What is your metabolic health score? How to tell if you have metabolic syndrome? And why should you care? We're diving into a custom method of analyzing metabolites, some of them were not available for analysis before. You'll hear about 47 metabolites and types of metabolites ML-powered actionable report the difference between NMR and MRI how does …
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How should blood feel when holding an endoscope controller? How – cutting through muscles? And why a gaming expert is employed in training surgeons? We're descending into the fascinating world where spine surgery meets Virtual Reality. You’ll hear about: ultra-minimally invasive endoscopic spine surgery, herniated disc, spinal stenosis, how haptics…
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It looks like they want to achieve impossible but when you listen closely to their plan – it totally makes sense. You’ll hear about Dr House and how can patients benefit from doctors working as a team the patient's role in the healthcare system low back pain management virtual team-based care clinical intelligence doctor shopping Baher Higazy and B…
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How many species inhabit a woman's vagina? If you're a woman, what kind of species are characteristic of your vagina? Now, you may learn that. And act on what you have learned to prevent recurring vaginal infections. How cool is that? You'll hear about: recurring vaginal infections, yeast infections, bacterial vaginosis, and STDs symptoms of vagina…
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When viagra doesn't work any more, here comes a new solution: erectile neuro-stimulator. A Swiss startup works on a minimally invasive implantable device that selectively activates the nerve to trigger penile erection. With a remote control. First prostatectomy patients have just had the device implanted – as part of a medical trial in Royal Melbou…
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So you have a panna cotta brain and so do I, no reason to worry, that's our biology. Now, how do you even try to place anything on that panna cotta – to record the activities of the brain or to send messages to the brain, like stopping shaking or pain, in severe diseases – so that you won't damage it? You’ll hear about how does brain-computer inter…
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You never know: it may be the worst pain in your life or barely "an inconvenience". Many believe the pain is worth it – set it and forget it, up to 10 years of birth control. IUD insertion hurts, right, but once in 10 years. But is that whole pain trully indespensable? Or is it there because women's pain has not been taken seriously enough? You’ll …
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