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Episode 31: The trouble with meta-analysis
Manage episode 407711024 series 3496374
Вміст надано Tom Chivers. Весь вміст подкастів, включаючи епізоди, графіку та описи подкастів, завантажується та надається безпосередньо компанією Tom Chivers або його партнером по платформі подкастів. Якщо ви вважаєте, що хтось використовує ваш захищений авторським правом твір без вашого дозволу, ви можете виконати процедуру, описану тут https://uk.player.fm/legal.
We all love to cite meta-analyses. They’re the review studies where scientists take every single piece of research ever published on a particular question, and then calculate the overall “true” effect across all of them. Putting together all those studies is a much better way to get to the truth… isn’t it?
In this episode of The Studies Show, Tom and Stuart give a intro to meta-analysis, and then talk about several major problems with the whole idea. Is meta-analysis—relied upon for making so many important scientific decisions, and cited in so many of our previous episodes—in serious need of a rethink?
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Show notes
Slide show from the Cochrane Collaboration on the basics of meta-analysis
Description of the GRADE guidelines for assessing study quality
Below is a funnel plot, a method of testing for publication bias in meta-analysis. Source: we asked an AI to randomly generate some data and display it in a funnel plot, just for illustration. This funnel plot is relatively symmetrical and probably wouldn’t indicate much publication bias:
Criticism of funnel plots; Nature news reporting on the criticism
Stuart’s Substack article on the homeopathy meta-analysis (and the retraction note for that meta-analysis)
The PET-PEESE technique for meta-analysis; and a criticism of it
Useful paper that compares between different bias-correction methods for meta-analysis
The p-curve website, which has the paper explaining the technique and a useful app where you can do your own p-curve
Stuart’s Substack article on the meta-analysis on “nudges”
Further criticism of the nudge meta-analysis, with important points about “meaningless means” (and yet more criticism)
Credits
The Studies Show is produced by Julian Mayers at Yada Yada Productions.
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