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The Malaria Legacy of Sickle Cell Disease
Manage episode 411571984 series 3531530
Вміст надано Johns Hopkins Malaria Research Institute and Johns Hopkins Bloomberg School of Public Health. Весь вміст подкастів, включаючи епізоди, графіку та описи подкастів, завантажується та надається безпосередньо компанією Johns Hopkins Malaria Research Institute and Johns Hopkins Bloomberg School of Public Health або його партнером по платформі подкастів. Якщо ви вважаєте, що хтось використовує ваш захищений авторським правом твір без вашого дозволу, ви можете виконати процедуру, описану тут https://uk.player.fm/legal.
Malaria is one of humanity’s oldest diseases – and one with which we have evolved.
Transcript
Malaria is one of humanity’s oldest diseases – and one with which we have evolved. Over time, it’s put selective pressure on our genome to respond better to its infection. Sickle cell disease is one example. It causes a defect in hemoglobin – transforming red blood cells into a banana or sickle shape – reducing the amount of oxygen transported to the body’s cells. The mutation has been around for more than 20,000 years – and is thought to originate near present-day Cameroon. But in one of the many evolutionary twists, under the right conditions, sickle cell disease can protect humans from malaria, because it makes it harder for malaria parasites to infect red blood cells. Possessing one copy is an asset, providing resistance to severe malaria, but if two copies of the mutation appear, it is a liability, leading to premature death. The evolutionary relationship between malaria endemicity and sickle cell disease is evident geographically. This complex, genetic legacy is the focus of an upcoming talk by Ambroise Wonkam at the Johns Hopkins Malaria Research Institute’s World Malaria Day symposium on April 25th.
Source
Evolutionary history of sickle-cell mutation: implications for global genetic medicine
About The Podcast
The Johns Hopkins Malaria Minute podcast is produced by the Johns Hopkins Malaria Research Institute to highlight impactful malaria research and to share it with the global community.
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