There’s only so much you can do in a week – or, according to Oliver Burkeman, in the roughly 4,000 weeks the average human lives. Oliver is a journalist and author of the books Four Thousand Weeks: Time Management for Mortals, Meditations for Mortals, and the newsletter “The Imperfectionist.” Chris and Oliver discuss the paradox of why change can only occur once we accept that we might not be able to change. Oliver also shares how life’s mishaps can become our most treasured memories and why sharing your imperfections is an act of generosity. For the full text transcript, visit go.ted.com/BHTranscripts For the full text transcript, visit go.ted.com/BHTranscripts For a chance to give your own TED Talk, fill out the Idea Search Application: ted.com/ideasearch . Interested in learning more about upcoming TED events? Follow these links: TEDNext: ted.com/futureyou Hosted on Acast. See acast.com/privacy for more information.…
Physician focused on the science of preventative health, aging, and athletic performance.
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Nick Sterling, MD, PhD

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How Bacteria in Your Gut Control Metabolic Health - Akkermansia & GLP-1 - Colleen Cutcliffe, PhD
48:02
Scientific knowledge of the gut microbiome has increased exponentially over the last decade. Recently, several studies have suggested that specific strains of bacteria, including Akkermansia muciniphila, are key to supporting the environmental conditions required for other related bacterial strains that facilitate healthy metabolic health. In this …
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Insulin resistance is a major risk factor for conditions like heart disease, stroke, and diabetes, yet its causes are not always well understood. This video explores the role of magnesium deficiency in insulin resistance and metabolic dysfunction, highlighting its impact on glucose metabolism, insulin signaling, and pancreatic function. We discuss …
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What are some common side effects of medications like Ozempic and Wegovy? From the front lines of healthcare, we explore adverse effects of these medications based on real-world visits to the emergency department. Learn about common side effects such as nausea, dehydration, and muscle wasting, as well as lesser-known risks like starvation ketosis a…
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Nick Sterling, MD, PhD

In this episode, we explore how ketamine, a dissociative anesthetic with a long history in medical use, is now being investigated for its rapid and sustained effects on depression, anxiety, and PTSD. We discuss its role in promoting neuroplasticity—rewiring the brain's structure to counteract stress-induced atrophy—and review the evidence from clin…
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In this episode, we talk about a recent study from Nature Aging that suggests aging may not progress in a straight line. Using data from thousands of biological measurements, researchers identified key ages—44 and 60—where changes in aging appear to accelerate. We review what this means for our understanding of aging, how it affects multiple system…
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Nick Sterling, MD, PhD

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Can we Slow the Speed of Aging? Biological Age & Epigenetics - Varun Dwaraka, PhD
1:23:41
1:23:41
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1:23:41Can we slow the speed of aging? In this episode, Dr. Varun Dwaraka, Head of Bioinformatics at TruDiagnostic, walks us through through the science of measuring "biological age" using epigenetic markers, such as DNA methylation. We discuss how epigenetics (i.e. DNA methylation), may provide biomarkers of biological age, the rate at which aging occurs…
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Nick Sterling, MD, PhD

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Preventing Atherosclerosis & Heart Disease (ApoB, Cholesterol, and Lipids) | Tom Dayspring, MD
1:16:10
1:16:10
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1:16:10Why do humans get cardiovascular disease and how can we prevent it? These are critical processes to understand for anyone who is interested in living a longer and healthier life. I'm very honored to talk with Dr. Tom Dayspring, a world-renowned clinical lipidologist and physician whose topic expertise is unparalleled. We discuss the underlying proc…
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Nick Sterling, MD, PhD

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Metabolic Health, Insulin Resistance, & Mitochondrial Health | Nicolas Verhoeven (Physionic)
1:08:41
1:08:41
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1:08:41In this episode, I had the pleasure of sitting down with Nicolas Verhoeven of Physionic. We focus our attention on metabolic health and, specifically, the energy-related, cellular, and nutritional mechanisms of insulin resistance. Nicolas reviews evidence pertaining to the reversal of insulin resistance and dietary clinical trials demonstrating rem…
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Nick Sterling, MD, PhD

In this episode, we discuss polarized training, which includes high-volume low intensity training and high-intensity training. We review the scientific literature pertaining to endurance performance, mechanisms of recovery debt, adaptations to various exercise modalities, and developing training programs around polarized training. MAF-180: https://…
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Nick Sterling, MD, PhD

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Muscle Loss & "Ozempic" - Prevention & What We Know | Nick Sterling, MD, PhD #8 | Nick Sterling, MD, PhD #8
8:49
Does muscle loss occur in people taking GLP-1 receptor agonists such as semaglutide (marketed as "Ozempic" and "Wegovy") or combined GLP-1/GIP agonists like tirzepatide (marketed as "Mounjaro")? In this episode, we discuss current evidence regarding these next-generation weight loss drugs and muscle wasting, as well as principles of preventing musc…
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Nick Sterling, MD, PhD

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How “Ozempic” Works – Weight Loss, Weight Regain, & Neuroscience | Nick Sterling, MD, PhD #7
11:04
How do drugs like Ozempic (semaglutide) cause weight loss? In this episode, we discuss how these drugs (GLP-1 receptor agonists) target specific areas in the brain to suppress appetite and facilitate weight loss. We also discuss clinical trials data suggesting that these drugs and/or the weight loss that they facilitate may have cardioprotective ef…
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Highly processed foods have been shown to lead to weight gain and are thought to drive intake through several mechanisms. Recent research suggests that the effect of combining fats and carbs on appetite might be more than the sum of their individual effects. Highly processed foods, accordingly, might simulate increased intake via the ratio of macro…
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Nick Sterling, MD, PhD

Growing scientific evidence suggests that highly processed foods are associated with increased risk of disease. Until recently, scientists were unable to study directly the effects of highly processed foods on humans. In this episode, we review one of the first highly controlled scientific trials demonstrating that ultra-processed foods lead to wei…
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Nick Sterling, MD, PhD

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How Overeating Rewires Our Brains – Neuroscience of Weight Gain & Loss | Nick Sterling, MD, PhD #4
31:40
In this episode, we discuss how overeating can lead to inflammation and neuron dysfunction in specific parts of the brain that control appetite and energy regulation. We review the neuroscience of appetite regulation, energy expenditure, and body fat regulation. Topics include hypothalamic dysfunction of body fat regulation, leptin resistance, neur…
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Nick Sterling, MD, PhD

Is it possible to be metabolically healthy and overweight or obese? In this episode, we discuss the science of what makes fat healthy or unhealthy. We discuss how metabolic dysfunction in fat tissue can affect the rest of the body. We also review evidence pertaining to the "obesity paradox" and explore explanations for the associations of body mass…
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Nick Sterling, MD, PhD

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How the Best Athletes "Burn" Fat for Fuel - Endurance Metabolism | Nick Sterling, M.D., Ph.D. #2
26:18
In this episode, we discuss fat through the lens of performance and survival, and what happens when we push our energy systems to their limits. We also talk about how our bodies make adaptations via exercise to improve our ability to "burn" fat for fuel, and how our bodies conserve fuel during times of negative energy balance. Lastly, we preview th…
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Nick Sterling, MD, PhD

This is our first episode on weight gain and weight loss. In this episode, we describe how, as an industrialized nation, our food supply and environment have changed in a way that, in many cases, is mismatched with our biology as humans. We explore how these changes can lead to disease and metabolic dysfunction. We discuss how the replacement of wh…
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