Flash Forward is a show about possible (and not so possible) future scenarios. What would the warranty on a sex robot look like? How would diplomacy work if we couldn’t lie? Could there ever be a fecal transplant black market? (Complicated, it wouldn’t, and yes, respectively, in case you’re curious.) Hosted and produced by award winning science journalist Rose Eveleth, each episode combines audio drama and journalism to go deep on potential tomorrows, and uncovers what those futures might re ...
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Вміст надано Aastha Jain. Весь вміст подкастів, включаючи епізоди, графіку та описи подкастів, завантажується та надається безпосередньо компанією Aastha Jain або його партнером по платформі подкастів. Якщо ви вважаєте, що хтось використовує ваш захищений авторським правом твір без вашого дозволу, ви можете виконати процедуру, описану тут https://uk.player.fm/legal.
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This Is Woman's Work with Nicole Kalil
Let’s talk about adulting— actual adulting. Not just paying bills or keeping a houseplant alive, but the kind that involves emotional maturity, healthy boundaries, and conscious self-leadership. Because let’s be honest, most of us weren’t taught how to be fully functioning adults… and it shows. Joining us is Michelle Chalfant , licensed therapist turned holistic life coach, creator of The Adult Chair® model, and author of the new book The Adult Chair: Get Unstuck, Claim Your Power, and Transform Your Life . With millions reached through her podcast, coaching programs, and retreats, she’s here to walk us through the five pillars of being a healthy, grounded adult. Here’s the truth: being an adult isn’t about checking boxes or pretending you’re fine. It’s about owning your truth. Feeling your feelings. Practicing compassion without letting yourself off the hook. It’s about setting firm boundaries—with no need for justification—and recognizing that your triggers are not flaws, they’re clues. None of us were handed a guidebook for how to grow up emotionally. We inherited patterns from people who were figuring it out as they went. But what Michelle shares today is empowering: it’s never too late to unlearn what no longer serves you and become the adult you were meant to be. Whether you’re starting this work or knee-deep in your personal development era, this episode will meet you where you are—and help you move forward with clarity, self-trust, and strength. Connect with Michelle: Website: https://theadultchair.com/ Book: https://theadultchair.com/book IG: https://www.instagram.com/themichellechalfant/?hl=en FB: https://www.facebook.com/@TheMichelleChalfant/ YouTube: https://www.youtube.com/c/michellechalfant Related Podcast Episodes: How To Build Emotionally Mature Leaders with Dr. Christie Smith | 272 Boundaries vs. Ultimatums with Jan & Jillian Yuhas | 297 Gentleness: Cultivating Compassion for Yourself and Others with Courtney Carver | 282 Share the Love: If you found this episode insightful, please share it with a friend, tag us on social media, and leave a review on your favorite podcast platform! 🔗 Subscribe & Review: Apple Podcasts | Spotify | Amazon Music Learn more about your ad choices. Visit megaphone.fm/adchoices…
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Вміст надано Aastha Jain. Весь вміст подкастів, включаючи епізоди, графіку та описи подкастів, завантажується та надається безпосередньо компанією Aastha Jain або його партнером по платформі подкастів. Якщо ви вважаєте, що хтось використовує ваш захищений авторським правом твір без вашого дозволу, ви можете виконати процедуру, описану тут https://uk.player.fm/legal.
The science of aging is moving rapidly and making progress at defeating age-related diseases and aging itself. Live Longer World takes you right where the action is happening! Through conversations with scientists, entrepreneurs, investors and other advocates revolutionizing the field of longevity science, we tell you how you can be disease-free, reverse aging, and maximize longevity in the future. https://livelongerworld.substack.com/
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Вміст надано Aastha Jain. Весь вміст подкастів, включаючи епізоди, графіку та описи подкастів, завантажується та надається безпосередньо компанією Aastha Jain або його партнером по платформі подкастів. Якщо ви вважаєте, що хтось використовує ваш захищений авторським правом твір без вашого дозволу, ви можете виконати процедуру, описану тут https://uk.player.fm/legal.
The science of aging is moving rapidly and making progress at defeating age-related diseases and aging itself. Live Longer World takes you right where the action is happening! Through conversations with scientists, entrepreneurs, investors and other advocates revolutionizing the field of longevity science, we tell you how you can be disease-free, reverse aging, and maximize longevity in the future. https://livelongerworld.substack.com/
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Can we detect cancer so early such that we find the very first cell of cancer? Not just stage 1 cancer, but the first cell of cancer. In this episode, Dr. Michael Levin and I speak with Dr. Azra Raza. She is an oncologist pioneering early detection of cancer using electric signals. So far, our best solution to curing cancer has been to detect it early, and she wants to take this further, by nipping cancer at the very first cell. Her story with cancer is also deeply personal as she lost her husband to the disease. You can see in the episode how much she cares about solving cancer through early detection, and how aggrieved she is about the fact that not only have we made zero progress on cancer in the last 100 years, but doctors are also not focused on cancer prevention. Dr. Raza is also the author of the book The First Cell: And the Human Costs of Pursuing Cancer to the Last. Episode Show Notes: https://livelongerworld.com/p/araza Find me: https://x.com/aasthajs My longevity products: https://www.livelongerworld.com/p/2024 TIMESTAMPS: 0:00 New theory of cancer 1:45 What causes cancer? 5:39 Hybrid cells in cancer 11:16 Why do cancer cells become immortal? 14:14 Detecting the first cell of cancer 17:09 Stress causes cancer cells to fuse 21:40 Cancer drugs don’t work universally 25:54 Personalization of early cancer detection 29:29 Detect cancer early using electrics 35:46 Anguish of cancer patients 39:06 Cancer progress hasn’t moved in 100 years 44:04 Doctors don’t think of cancer prevention 46:54 First Cell Therapeutics - Azra’s company 50:55 What is the first cell stage of cancer? 54:55 Advice for cancer patients AASTHA, LIVE LONGER WORLD: Twitter: https://x.com/aasthajs Newsletter: https://livelongerworld.com/ Instagram: https://www.instagram.com/aasthajs/ LINKS: Michael Levin: https://twitter.com/drmichaellevin Azra Raza: https://azraraza.com/ Azra Raza book The First Cell: https://amzn.to/4jGJzoJ Episode Show Notes: https://livelongerworld.com/p/araza RELATED EPISODES: Keto & Metabolic Therapy for Cancer | Dr. Thomas Seyfried: https://open.spotify.com/episode/7tYdjcJ3G4tqbAx9Z6Bix2?si=gboyPAiLQrqg-y5YEKQiQQ Why Viruses Could Be the Cause of Chronic Disease | Dr. Paul Ewald: https://open.spotify.com/episode/2OdYInlzTy2zG3Mi6TgADY?si=Gnbg7efNSy21bS3q0c23jg…
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1 Hidden Viruses Cause Cancer & Alzheimer's | Dr. Paul Ewald 1:31:16
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Відтворити Пізніше Відтворити Пізніше Списки Подобається ПодобаєтьсяWhat if chronic diseases like cancer and Alzheimer’s are caused by infections we’ve overlooked? We assume chronic disease is caused by genetics and / or lifestyle. However, evolutionary biologist Dr. Paul Ewald says latent viruses and pathogens play a critical hidden role in many diseases. For example, we already know that Human Papillomavirus (HPV) causes cervical cancer. And research indicates how the EBV virus shows up in Multiple sclerosis, and chlamydia pneumonia shows in Alzheimer’s. Deeper investigation into viruses and disease is warranted and will help with better diagnosis and treatment. Dr. Paul Ewald is also the author of Plague Time: The New Germ Theory of Disease, and Evolution of Infectious diseases. Episode Show Notes: https://livelongerworld.com/p/pewaldFind me: https://x.com/aasthajs My longevity products: https://www.livelongerworld.com/p/2024TIMESTAMPS:0:00 Role of infection in chronic disease is neglected 2:40 Role of viruses in Alzheimer’s 10:50 Connections between Alzheimer’s, diabetes, cardiovascular disease 15:57 Genes cannot explain the full reason for disease 20:47 Strong association between Alzheimer’s, chlamydia pneumonia, and APOE4 28:16 Multiple sclerosis and EBV virus 35:08 Latent viruses may in fact be active & cause cancer 41:41 Sexually- transmitted pathogens correlated with cancer 46:50 Viruses that cause cancer (EBV & breast cancer) 53:09 Hodgkin’s lymphoma and virus 57:15 Stanford study showing EBV as leading cause of MS 1:00:19 Do viruses attack the mitochondria and cause cancer 1:01:38 Glioblastoma and virus / antiviral treatment 1:07:07 Virus vs. oncogenes causing cancer 1:14:17 Breast cancer BRAC1 mutations & virus association 1:15:59 Vaccines against viruses 1:17:56 Practical steps if you test positive for infectious viruses 1:24:57 Could cancer relapse be due to persistent virus 1:27:48 Protect the immune system 1:29:38 Areas Dr. Ewald is excited aboutAASTHA, LIVE LONGER WORLD:X: https://x.com/aasthajs Newsletter: https://livelongerworld.com/Instagram: https://www.instagram.com/aasthajs/PAUL EWALD LINKS:Plague Time: The New Germ Theory of Disease: https://amzn.to/3FXjOSuEvolution of Infectious diseases: https://amzn.to/3FYaqOvEpisode Show Notes: https://livelongerworld.com/p/pewaldALSO WATCH:Keto & Metabolic Therapy for Cancer | Dr. Thomas Seyfried: https://open.spotify.com/episode/7tYdjcJ3G4tqbAx9Z6Bix2?si=biOOH1e5RpeZduLJv2fPHw…
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1 Michael Levin & Pamela Lyon | Rethinking Cognition for Longevity 1:11:57
1:11:57 Відтворити Пізніше Відтворити Пізніше Списки Подобається Подобається1:11:57
Відтворити Пізніше Відтворити Пізніше Списки Подобається ПодобаєтьсяWhat if our cells have memory and cognition, which changes how medicine is done? In this conversation with Dr. Pamela Lyon and Dr. Michael Levin, we discuss: - Cognition and creativity is not merely associated with the brain and nervous system - Implications of this view of cognition for regenerative medicine and longevity - Is stress response the source of our creativity? Episode Show Notes: https://livelongerworld.com/p/plyon Find me: https://x.com/aasthajs My longevity products: https://www.livelongerworld.com/p/2024 TIMESTAMPS: 0:00 Intro, Basal cognition 1:00 Our view of cognition is incorrect 8:50 What does biology have to say about cognition? 12:12 Cognition in xenobots 14:20 Cognition and cooperation in microbes 30:03 Bioelectricity and cognition 33:58 Is stress response the source of our creativity? 43:27 Mike’s paper: Stress-sharing as a cognitive glue 47:31 Implications of cognition not only being associated with brain 56:55 Cognition in AI 1:02:33 View of cognition in the East AASTHA, LIVE LONGER WORLD: Twitter: https://x.com/aasthajs Newsletter: https://livelongerworld.com/ Instagram:https://www.instagram.com/aasthajs/ LINKS: Michael Levin: https://twitter.com/drmichaellevin Pamela Lyon: https://www.adelaide.edu.au/directory/pamela.lyon# Episode Show Notes: https://livelongerworld.com/p/plyon ALSO WATCH: Michael Levin & Denis Noble on What Biology Needs to Advance Longevity: https://open.spotify.com/episode/49WaTa4Vl67FU4zjjX1H6F?si=x1rjzVocS2OjSVdxpzNt5g…
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1 Boost Mitochondria with Sunlight & Infrared light | Glen Jeffery 1:37:53
1:37:53 Відтворити Пізніше Відтворити Пізніше Списки Подобається Подобається1:37:53
Відтворити Пізніше Відтворити Пізніше Списки Подобається ПодобаєтьсяWe’re only just waking up to the benefits of sunlight and red light for mitochondrial health, lowering blood glucose, and potentially treating Parkinson’s disease and cancer. Dr. Glen Jeffery is at the leading edge of this research. We discuss: - Health benefits of sunlight and red light - Harmful effects of blue light & LEDs - In the 2nd half of the podcast, I ask him rapid fire practical questions that everyone wants to know about light, ranging from how much sunlight should one get to what time of day is best for infrared light exposure. Episode Show Notes: https://livelongerworld.com/p/gjeffery Find me: https://x.com/aasthajs TIMESTAMPS: 0:00 Intro 0:59 Light impact on public health 3:08 Light research is understudied, mitochondria is impacted by light 6:05 Red and blue light impacts on mitochondria 8:25 Benefits of red light - wound healing, lower glucose 15:09 Are there downsides to red light? 16:59 Does time of day impact red light benefits? 22:05 Red light and cancer 26:00 Blue light is making you pre-diabetic 37:46 n=1 light experiments 39:22 Mitochondria & Longevity 46:21 “Sunlight offers a unique package” Rapid fire questions: 53:40 Is sunlight good enough for red light? 55:10 How much sunlight do we need? 56:07 When should you get sunlight? 56:55 Should you worry about afternoon sunlight? 58:57 Can you get sunlight on cloudy days? 59:38 Does sunscreen mitigate benefits of sunlight? 1:00:12 Should you not wear caps and sunglasses in sunlight 1:01:43 Clothing and sunlight 1:05:52 Sunlight through window? 1:06:16 Are blue light blocking glasses helpful? (see 1:19:31 for more context) 1:08:17 Do Artificial sunlight lamps work? 1:08:51 What wavelength red light is the best? 1:10:56 Time in front of red light device 1:12:41 Body exposure to red light 1:15:37 Lighting at home at night 1:19:31 Differences in blue light for mitochondria vs. circadian biology 1:24:18 Stop using LEDs 1:25:24 Does light impact the bioelectrics of the mitochondria? 1:26:55 Mitochondria in melatonin mop up ROS 1:31:29 Benefits of fire light? 1:35:33 Open questions on light and health 1:37:28 Support Live Longer World AASTHA, LIVE LONGER WORLD: X: https://x.com/aasthajs Newsletter: https://livelongerworld.com/ Instagram: https://www.instagram.com/aasthajs/ DR. GLEN JEFFERY: Bio page: https://profiles.ucl.ac.uk/7465-glen-jeffery/publications ALSO WATCH:- Keto & Metabolic Therapy for Cancer | Dr. Thomas Seyfried: https://open.spotify.com/episode/7tYdjcJ3G4tqbAx9Z6Bix2?si=rHlCwLVqQHqiOB7yTVBtgQ…
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1 Keto Diet & Metabolic Therapy for Cancer | Dr. Thomas Seyfried 1:21:56
1:21:56 Відтворити Пізніше Відтворити Пізніше Списки Подобається Подобається1:21:56
Відтворити Пізніше Відтворити Пізніше Списки Подобається ПодобаєтьсяDr. Thomas Seyfried challenges the existing paradigm that says cancer is a genetic disease. He says that instead cancer is caused by damage to the mitochondria. Understanding this completely overturns the management and prevention of cancer. He is a Professor of biology, genetics, and biochemistry at Boston College. He has over 150 peer-reviewed publications and is also the author of books such as, ‘Cancer as a Metabolic Disease: On the Origin, Management, and Prevention of Cancer’. WE DISCUSS: - Why cancer is not a genetic disease - Why cancer is a metabolic disease originating from damage to the mitochondria - How metabolic therapy, management of glucose and glutamine, can be used to manage cancer - His December 2024 paper outlining a proposal for ketogenic metabolic therapy in glioblastoma Episode Show Notes: https://livelongerworld.com/p/tseyfried Find me: https://x.com/aasthajs TIMESTAMPS: 0:00 Cancer is not a genetic disease 5:04 Origins of somatic mutation theory of cancer 8:04 Mitochondrial damage causes cancer 13:42 Is mitochondrial dysfunction involved in every cancer 16:14 Mitochondria in cancer cells ferment 21:52 Target glucose and glutamine to manage cancer 28:51 Hyperbaric Oxygen therapy for cancer 31:04 December 2024 study: Role of glutamine in cancer 33:35 Can metabolic therapy be done at any stage of cancer 36:44 Combine chemotherapy with metabolic therapy 38:05 Drugs to target glutamine 40:30 People will say “I want metabolic therapy” 44:04 “Failure to understand biology” 47:48 National Cancer Institute’s take on Dr. Seyfried’s theory 49:34 Why does Peter Attia think cancer is a genetic disease 53:09 “I think about this 24/7; we’re right!” 55:56 Glioblastoma treatment protocol study 59:22 Resistance to breakthrough ideas in science 1:01:40 Radiation fuels cancer! 1:04:52 Current standard of care is responsible for poor survival rate in glioblastoma 1:07:14 Metabolic therapy for epilepsy, Parkinson’s, Alzheimer’s 1:12:22 How to prevent cancer 1:13:49 Young, healthy individuals in their 20s, 30s with cancer 1:15:05 Resources on following metabolic therapy 1:17:43 How to support Dr. Seyfried’s research 1:18:51 New cancer questions Dr. Seyfried is researching 1:21:32 Closing thoughts AASTHA, LIVE LONGER WORLD: X: https://x.com/aasthajs Newsletter: https://livelongerworld.com/ Instagram: https://www.instagram.com/aasthajs/ DR. THOMAS SEYFRIED: X: https://x.com/tnseyfried Bio page: https://www.bc.edu/bc-web/schools/morrissey/departments/biology/people/faculty-directory/thomas-seyfried.htmlCancer as a Metabolic disease book: https://amzn.to/3WBF31D RELATED EPISODES: The Cancer-Diet Connection & Otto Warburg - Nobel Prize Scientist under Hitler | Sam Apple, Author of Ravenous Modified Ketogenic Diet for Optimal Health & Exercise | Dr. Dominic D'Agostino Ketogenic Diet for Brain Health & Longevity | Dr. Dominic D'Agostino The Evolutionary Theory of Cancer | Charley Lineweaever Bioelectricity and Cancer w/ Michael Levin…
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1 Denis Noble & Michael Levin | What Biology needs to Advance Longevity 1:08:00
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Відтворити Пізніше Відтворити Пізніше Списки Подобається ПодобаєтьсяDenis Noble and Michael Levin - two great minds in biology come together on Live Longer World. Denis Noble is a renowned biologist and pioneer in systems biology, known for his groundbreaking work on the electrical activity of the heart and his influential contributions to the understanding of biological systems. Denis is an advocate for taking a systems integrative approach to biology, as opposed to the reductionist gene-centric view that has dominated the field due to Neo-Darwinism. The gene-centric view has failed us in advancing progress on many diseases, and we need to now take a systems based approach focused on functional networks within biological systems. Michael Levin is an American developmental and synthetic biologist at Tufts University, where he is the Vannevar Bush Distinguished Professor. His research is focused on bioelectricity and he is my co-host for this podcast. We discuss: - DNA is not the blueprint of life - Why biology’s reductionist approach is flawed - The errors in Neo-Darwinism - Epigenetic inheritance - How to advance the cure of diseases Episode Show Notes: https://livelongerworld.com/p/dnoble Find me: https://x.com/aasthajs TIMESTAMPS: 0:00 Denis as Mike Levin’s hero 0:10 Denis’s journey to systems biology; cell voltage is a global property of the cell 3:45 Advice to young researchers pursuing systems biology 7:00 “Absolutely everything is wrong with Neo-Darwinism” 14:10 Epigenetic inheritance 19:12 Genetic vs. other information used by organisms 23:48 Biology textbooks have to expand beyond DNA in 50 years 25:03 Epigenetic processes are ubiquitous 28:58 If not DNA, what is the blueprint of life 36:15 Rewriting biology textbooks is fundamental 39:57 “A lot of time has been wasted” (in biology) 46:52 Darwin on the “Origin of Species” 55:38 “Unfortunate that Philosophy and science have diverged” 1:00:31 Importance of Functional networks; DNA does not predict disease AASTHA, LIVE LONGER WORLD: Twitter: https://x.com/aasthajs Newsletter: https://livelongerworld.com/ Instagram: https://www.instagram.com/aasthajs/ LINKS: Michael Levin: https://twitter.com/drmichaellevin Denis's book Dance to the Tune of Life: https://a.co/d/3hvh5JW Episode Show Notes: https://livelongerworld.com/p/dnoble Michael Levin on Bioelectric Signals for Longevity: https://youtu.be/XboYI_wxDr8?si=WrQ_iI8ABbG6eibm…
This interview is part of my series with Dr. Michael Levin where we interview significant people in the history of developmental bioelectricity. Dr. Mustafa Djamgoz was one of the first people to study the role of ion channels and bioelectricity in cancer, which he initially documented in a 1995 paper. His research showed that there was an uptake in voltage-gated sodium channels in all types of cancer metastasis, except prostate cancer, highlighting the significant role of studying ion channels in cancer. Simply put, the spread of cancer cells is linked to increased activity in sodium ion channels, which regulate electrical currents in our cells. Episode Show Notes: https://livelongerworld.com/p/mdjamgoz Find me: https://x.com/aasthajs Background on the bioelectricity series & 1st episode with Dr. Richard Nuccitelli: https://youtu.be/DtUqOwTRvz0?si=3OJryM0yJjzfQtfo TIMESTAMPS: 0:00 Playing with radios at age 17 to bioelectricity cancer research 4:31 Advice for young people entering bioelectricity 9:02 Biophysics and Cancer neuroscience 17:55 Role of bioelectricity in cancer 27:02 Cancer metastasis and ion channels 28:49 Sodium channel uptake and cancer invasiveness 36:59 Ranolazine, potential anti-metastatic drug 43:45 Funding for bioelectricity cancer research 50:21 Advice for cancer patients AASTHA, LIVE LONGER WORLD: Twitter: https://x.com/aasthajs Newsletter: https://livelongerworld.com/ Instagram: https://www.instagram.com/aasthajs/ Michael Levin: https://twitter.com/drmichaellevin Mustafa's publications: https://profiles.imperial.ac.uk/m.djamgoz/publications Mustafa's book Beat Cancer: https://www.amazon.com/Beat-Cancer-Regain-Control-Health-ebook/dp/B00CU8QBAS Episode Show Notes: https://livelongerworld.com/p/djamgoz Michael Levin on Bioelectric Signals for Longevity: https://youtu.be/XboYI_wxDr8?si=WrQ_iI8ABbG6eibm…
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1 Genes are NOT the "blueprint of life" | Dr. Alfonso Martinez Arias 1:20:50
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Відтворити Пізніше Відтворити Пізніше Списки Подобається ПодобаєтьсяDr. Alfonso Martinez Arias is a development biologist and the author of the book The Master Builder: How the New Science of the Cell Is Rewriting the Story of Life. He also co-authored the biology textbook Principles of Development, which was awarded the Royal Society of Biology book prize. Episode Show Notes: https://livelongerworld.com/p/aarias OVERVIEW: Each of our cells has the same DNA. Yet they somehow differentiate into different body parts - eyes, ears, skin, and so on. There is no information in the DNA that tells our cells what to be. How then do they do it? This is just one example of how contrary to what many might think, DNA does not explain every problem state in biology. Biology has placed too much emphasis on our genes, trying to explain every disease state using genes, when the answer might not reside with them. What if answers to these questions lies with cells? Even though Dr. Martinez started off as a geneticist, he decided to pivot to understand the properties of cells better. By understanding our cells better, we can make further progress in understanding disease, longevity, and development. Towards the end, we also talk about Alfonso's fascinating work on gastruloids which are a model to unravel the mysteries of embryonic development, and understand how humans are formed. This conversation is about the cell’s eye view of biology, and how the gene's eye view of biology might have mislead us. We also talk about why the popular selfish gene theory espoused by Richard Dawkins is incomplete. Looking beyond genes is instrumental to making progress in longevity. Episode Show Notes: https://livelongerworld.com/p/aarias Find me: https://x.com/aasthajs TIMESTAMPS: 0:00 Intro 1:15 DNA does not make us unique 5:28 Cells use our genes 10:42 “We have overstretched what genes can explain” 15:41 Relation between genes and cells 20:28 What about the role of epigenetics? 22:42 Cells use mechanical and chemical signals 27:34 Thoughts on bioelectricity and Michael Levin 32:28 Emergence of cells 38:10 Importance of biophysics; What is life? 42:32 Is cancer when cells lose control? 47:58 Richard Dawkins’ Selfish Gene is Incomplete 54:11 But what if genes control development? 57:29 How to complete the selfish gene view? 1:02:05 Cell’s eye view of biology 1:04:48 Understanding embryonic development; gastruloids 1:18:15 Questions Dr. Alfonso is pursuing1:19:47 Thoughts from Feynman AASTHA, LIVE LONGER WORLD: X: https://x.com/aasthajs Newsletter: https://livelongerworld.com/ Instagram: https://www.instagram.com/aasthajs/ DR. ALFONSO MARTINEZ ARIAS: Master Builder book: https://www.amazon.com/Master-Builder-Science-Rewriting-Story/dp/1541603273 X: https://x.com/AMartinezArias Bio page: https://www.icrea.cat/Web/ScientificStaff/alfonso-martinez-arias-352001…
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1 The Evolutionary Theory of Cancer | Dr. Charley Lineweaver 1:05:12
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Відтворити Пізніше Відтворити Пізніше Списки Подобається ПодобаєтьсяThe following is a fascinating interview with Dr. Charley Lineweaver, who worked with Paul Davies on his work on cancer which we discuss. Episode Show Notes: https://livelongerworld.com/p/clineweaver Topics include: - the evolutionary and atavistic theory of cancer - the incorrectness of the somatic mutation theory of cancer - a novel take on attacking the weakness of cancer - how embryogenesis could be viewed as cells reverting to old memory - the origins of multicellularity - “Cancer cannot do anything new” The atavistic theory of cancer states that cancer cells revert to an old memory they have from billions of years, but forget the new memory. The old memory pertains to constant cell proliferation, which happened as single-celled creatures, and in fact in embryogenesis as well. The new memory pertains to regulating cell proliferation and cells knowing when to stop cellular division. In cancer, it seems like cells forget this new memory and revert to the old memory. This theory has many interesting explanations and predictions which we dive into in the conversation. Enjoy! Episode Show Notes: https://livelongerworld.com/p/clineweaver Find me: https://x.com/aasthajs TIMESTAMPS: 0:00 Background in astrobiology 1:53 Evolutionary theory of cancer 6:22 Atavistic model: Cancer cells go back to “original state” 9:50 Atavistic theory vs. Cancer 14:44 Somatic Mutation Theory of Cancer is Wrong 22:36 Disagreement with Mike Levin’s work 24:17 Attack the weakness of cancer 27:45 Vaccine for cancer 38:08 Wound healing and cancer 41:23 Why new genes are more susceptible to damage 45:26 Origins of multicellularity 48:49 Predictions of Atavistic model 53:45 Cancer cells spread 56:52 Cell proliferation, Cancer, Hayflick limit 58:54 Doctors are not trained in evolution AASTHA, LIVE LONGER WORLD: Twitter: https://x.com/aasthajs Newsletter: https://livelongerworld.com/ Instagram: https://www.instagram.com/aasthajs/ DR. CHARLEY LINEWEAVER: Website: https://researchers.anu.edu.au/researchers/lineweaver-ch Papers referenced: - Cancer progression as a series of atavistic reversions: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8860064/ - Targeting cancer's weaknesses, not its strengths: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4282648/…
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1 Michael Levin & Ken Robinson | Bioelectricity in the era of the Genetic Code 1:01:26
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Відтворити Пізніше Відтворити Пізніше Списки Подобається ПодобаєтьсяThis is the third in my series with Dr. Michael Levin where we interview significant people in the history of developmental bioelectricity. Ken Robinson has a long list of accomplishments in the bioelectricity field, covering the role of electric fields in guiding cell migration and more generally the function of electrogenic epithelia in embryogenesis. This is about a ~1 hour conversation in which he talks about his background, the history of the field, and his time in Lionel Jaffe's lab. Episode Show Notes: https://livelongerworld.com/p/krobinson Find me: https://x.com/aasthajs Background on the bioelectricity series & 1st episode with Dr. Richard Nuccitelli: https://www.livelongerworld.com/p/rnuccitelli TIMESTAMPS: 0:00 Intro 0:38 Ken’s background - From physics to bioelectricity 6:10 Bioelectricity in the era of the “genetic code” 10:27 Ken’s first experiments in ion movement using light 23:25 Proton pump and its significance 26:07 Neurons respond to electrical signals 36:26 Working in Lionel Jaffe’s lab 47:39 Mike Levin as an undergrad 48:49 Membrane potential left-right asymmetry in cells 52:59 Epithelia is powerfully electrogenic 57:49 Advances for bioelectricity 59:27 Underrated people in the field AASTHA, LIVE LONGER WORLD: Twitter: https://x.com/aasthajs Newsletter: https://livelongerworld.com/ Michael Levin: https://twitter.com/drmichaellevin Mike's bibliography of bioelectricity: https://thoughtforms.life/my-reference-lists-whole-endnote-library-and-bibliography-on-bioelectromagnetics/ Episode Show Notes: https://livelongerworld.com/p/krobinson Michael Levin on Bioelectric Signals for Longevity: https://youtu.be/XboYI_wxDr8?si=WrQ_iI8ABbG6eibm…
This is the second of several interviews Michael Levin and I will do with significant people in the history of developmental bioelectricity. Min Zhao's work is focused on the role of ion currents and applied electric fields in cell migration and wound repair. Episode Show Notes: https://livelongerworld.com/p/mzhao Find me: https://x.com/aasthajs Background on the bioelectricity series & 1st episode with Dr. Richard Nuccitelli: https://youtu.be/DtUqOwTRvz0?si=3OJryM0yJjzfQtfo TIMESTAMPS: 0:00 Min’s background from trauma surgery to bioelectricity 5:14 Bioelectricity in wound healing 13:51 Potential and challenges of bioelectricity in wound healing 21:40 Min’s take on Robert Becker’s work 24:53 Scientists in the field Min drew got inspired by 29:36 The era before Lionel Jaffe 32:39 Experiments in wound healing using bioelectricity 45:43 Min’s current explorations AASTHA, LIVE LONGER WORLD: Twitter: https://x.com/aasthajs Newsletter: https://livelongerworld.com/ Michael Levin: https://twitter.com/drmichaellevin Min Zhao: https://health.ucdavis.edu/dermatology/faculty/zhao.html Episode Show Notes: https://livelongerworld.com/p/mzhao Michael Levin on Bioelectric Signals for Longevity: https://youtu.be/XboYI_wxDr8?si=WrQ_iI8ABbG6eibm…
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1 Glyphosate Toxicity & Deuterium's Role in Cancer, Celiac, Aging | Dr. Stephanie Seneff 1:18:39
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Відтворити Пізніше Відтворити Пізніше Списки Подобається ПодобаєтьсяStephanie Seneff is the pioneer in raising concerns around glyphosate, a chemical and active ingredient in RoundUp and other pesticides, which has practically infiltrated our food system, water bodies, and soil. Glyphosate has been linked to several diseases including liver disease, autoimmunity, neurological disorders, reproductive issues, microbiome problems, and more. Dr. Stephanie Seneff has spent 10+ years researching glyphosate’s harmful impact on our health, and documented her findings in her book Toxic Legacy: How the Weedkiller Glyphosate is Destroying our Health and the Environment. More recently, Stephanie has been doing research on deuterium (a hydrogen isotope in the body) and how glyphosate can cause an excess of deuterium, potentially leading to cancer and other health consequences. Glyphosate is affecting each one of us. It’s worth paying attention to this toxic chemical. Episode Show Notes: https://livelongerworld.com/p/sseneff Find me (Aastha) on X: https://x.com/aasthajs DR. STEPHANIE SENEFF LINKS: Website: https://stephanieseneff.net/ X: https://x.com/stephanieseneff Book: https://www.amazon.com/Toxic-Legacy-Stephanie-Seneff/dp/1603589295/ AASTHA, LIVE LONGER WORLD: X: https://x.com/aasthajs Newsletter: https://livelongerworld.com/ Instagram: https://www.instagram.com/aasthajs/ Airchat: https://www.getairchat.com/aasthajs TIMESTAMPS: 0:00 Autism in children, vaccines, glyphosate 2:30 Aluminum and fluoride in water 3:47 Glyphosate in our food and its toxicity 6:05 Celiac’s link to glyphosate 8:25 Glyphosate impacting collagen in our bodies 12:55 Soil regeneration after glyphosate 15:24 Breaking down glyphosate in our waterways 16:36 Glyphosate causing sulfate deficiency; cruciferous veggies 18:43 Sulfate powers bioelectricity in our cells; Gerald Pollack 21:23 Avoid sunscreen? 22:25 Deuterium and its toxicity 25:20 How Stephanie started looking at Deuterium 26:36 Low deuterium water good for health? 29:25 Excess deuterium causing cancer 30:52 Stephanie’s wild theory on curing cancer 35:19 What else causes increase in deuterium 35:38 Glyphosate in rain water 36:25 PSCSK9 inhibitors harmful with glyphosate 38:49 Solutions to avoid glyphosate 42:23 U.S. stopped Mexico banning glyphosate Episode Show Notes: https://livelongerworld.com/p/sseneff…
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1 Michael Levin & Richard Nuccitelli | History of Bioelectricity & Solving Cancer 1:04:53
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Відтворити Пізніше Відтворити Пізніше Списки Подобається ПодобаєтьсяThis is the first of several interviews Michael Levin and I will do with significant people in the history of developmental bioelectricity. Richard Nuccitelli is a legend, having invented (with Lionel Jaffe, in 1974) the Vibrating Probe - a technique that allowed the non-invasive sensing of ion currents around living tissues. This is about a ~1 hour conversation in which he talks about his background, the history of the field, and his current clinical work on the bioelectrics of cancer. Episode Show Notes: https://livelongerworld.com/p/rnuccitelli Find me: https://twitter.com/aasthajs BACKGROUND: In 2022, I interviewed Dr. Michael Levin on his work on bioelectricity in cells and how that has the potential to solve cancer and aging. Since then, Mike has also appeared on Lex Fridman and many other podcasts talking about his revolutionary work. Amongst all the podcasts I did, Mike’s work struck me as profound yet underappreciated. The field of biology has focused on the DNA and the relevance of the electric currents in our cells is not appreciated. Yes, the electrical energy powering our cells is what keeps us alive! Earlier this year, I decided to dive deeper into bioelectricity. I’m starting by exploring the history of the field in conjunction with Michael Levin. We’re doing a series of interviews talking to scientists in the field to understand the origins of the field, bottlenecks, progress so far, and what the future could look like. Today's interview is the first in the series with Dr. Richard Nuccitelli. TIMESTAMPS: 0:00 Intro to History of Bioelectricity Series 1:09 How Rich got interested in bioelectricity 4:34 Bioelectrics didn't make it to biology literature 7:55 Vibrating probe use cases 10:20 Bioelectrics in 1970s 13:37 Why is bioelectrics underrated? 22:50 Field progression 29:02 Ultra high voltage in treating cancer 39:00 Understanding significance of bioelectrics from 1900s 44:40 Working with Lionel Jaffe 50:27 How Mike entered bioelectrics 54:02 Criticism received by bioelectrics? 57:04 Missing technology to advance bioelectrics 1:00:52 Electrical patterns in cells with age 1:03:12 Image of electrics in organisms AASTHA, LIVE LONGER WORLD: Twitter: https://twitter.com/aasthajs Newsletter: https://livelongerworld.com/ Instagram: https://www.instagram.com/aasthajs/ Airchat: https://www.getairchat.com/aasthajs Michael Levin: https://twitter.com/drmichaellevin Richard Nuccitelli: https://www.linkedin.com/in/nuccitelli/ Episode Show Notes: https://livelongerworld.com/p/rnuccitelli Michael Levin on Bioelectric Signals for Longevity: https://youtu.be/XboYI_wxDr8?si=WrQ_iI8ABbG6eibm…
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1 FDA History and Breast Cancer Drug Controversy | Dr. Mikkael Sekeres 1:05:01
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Відтворити Пізніше Відтворити Пізніше Списки Подобається ПодобаєтьсяDr. Mikkael Sekeres is the author of the book The Drugs and FDA. He served as the chair of the Oncology Drugs Advisory Committee of the FDA, and was on the jury for the controversial trial of the breast cancer drug Avastin. We discuss: - The history of the FDA, - The trial of Avastin which got FDA approval in 2008 and revoked in 2011 - FDA's funding mechanisms - FDA ties to big pharma - What can be improved about the FDA and the criticisms it receives Episode Show Notes: https://livelongerworld.com/p/msekeres TIMESTAMPS: 0:00 Surprising finding about the FDA 2:38 Why did the FDA get established in 1938? 11:48 1962 turning point in the FDA & Thalidomide 19:57 Kennedy’s efficacy act on drugs approval 25:40 FDA’s accelerated approval; HIV & AIDS 33:23 Avastin breast cancer drug controversy 41:13 Why was Avastin trial contentious? 45:23 Genentech’s argument 50:00 Media reaction 53:21 FDA funded by big pharma 56:39 FDA vs. patient activist groups 59:50 Opioid crisis 1:03:30 Does the FDA go against advisory committee? CONNECT WITH AASTHA, LIVE LONGER WORLD: Twitter: https://twitter.com/aasthajs Newsletter: https://livelongerworld.com/ Instagram: https://www.instagram.com/aasthajs/ Airchat: https://www.getairchat.com/aasthajs DR. MIKKAEL SEKERES LINKS: Website: https://www.mikkaelsekeres.com/ Twitter: https://twitter.com/MikkaelSekeres Book: https://www.amazon.com/Drugs-FDA-Safety-Efficacy-Publics/dp/0262047314 If you enjoyed the episode, please share it and leave a rating. Best, Aastha.…
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1 #27 Women's Reproductive Aging, Menopause, & Hormone Replacement Therapy | Dr. Jennifer Garrison 1:03:06
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Відтворити Пізніше Відтворити Пізніше Списки Подобається ПодобаєтьсяDr. Jennifer Garrison is a an Assistant professor at the Buck Institute for research on aging where she studies women's reproductive aging. In today’s conversation we discussed menopause and it’s effect on women’s health, hormone replacement therapy, and how increasing the number of quality eggs a woman has at age 40 by just 1% can be a game changer. Episode Show Notes: https://livelongerworld.com/p/jgarrison Find the previous podcast episodes & subscribe to be notified: https://livelongerworld.com/ Find me (Aastha) on Twitter: https://twitter.com/aasthajs DR. JENNIFER GARRISON LINKS: Lab: http://garrisonlab.com/ Donate to her research: https://gcrle.org/ CONNECT WITH AASTHA, LIVE LONGER WORLD: Twitter: https://twitter.com/aasthajs Newsletter: https://livelongerworld.com/ Instagram: https://www.instagram.com/aasthajs/ Airchat: https://www.getairchat.com/aasthajs TIMESTAMPS: 00:00 Intro 1:38 Jennifer Garrison Intro 2:32 Ovarian aging & health risks 5:23 Progression of Ovarian aging 8:49 Menopause and negative health effects 10:34 Hypothalamus & Mind body communication 14:40 Reproductive & Equality Initiatives 18:21 Biological Clock for Reproductive aging 20:20 Tweaking hormonal cues 22:07 Number of eggs vs. Quality of eggs 25:00 Genetics in ovarian aging 26:21 Understanding family history 27:39 Evolutionary benefit to Menopause? 32:33 Hormone Replacement Therapy (HRT) & its benefits 38:28 Narrow window for HRT 40:08 Perimenopause 42:56 Women’s health funding 45:14 Average age girls start menstruating is declining 49:10 PCOS 52:42 Athletes and irregular cycles 56:36 Individualized menopause symptoms 1:00:38 Exercise and ovarian aging 1:02:00 Support Jennifer's work Episode Show Notes: https://livelongerworld.com/p/jgarrison POPULAR EPSIODES: - Richard Miller on Longevity Supplements: https://youtu.be/42PzfNs9egA - Matt Kaeberlein on Rapamycin: https://youtu.be/BL67DhNepfg - Michael Levin on Bioelectric Signals for Longevity: https://youtu.be/XboYI_wxDr8 - Nir Barzilai on Metformin & Centenarians: https://youtu.be/YlkBE8N7sl8 - Morgan Levine on Epigenetic Clocks: https://youtu.be/am3YKiTpCHo Thanks for watching & if you enjoy the episode, let's spread the message on longevity. You can support my work by sharing, liking, subscribing, leaving a review on Apple podcasts, or signing up as a premium member. Aging is universal. Let's unite in this fight. Stay in good health - Aastha.…
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1 #26 Scaling Laws in Longevity & Aging | Dr. Geoffrey West, Author of book Scale 2:03:25
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Відтворити Пізніше Відтворити Пізніше Списки Подобається ПодобаєтьсяDr. Geoffrey West is the author of the bestselling book Scale, the Universal Laws of Life Growth and Death in Organisms, cities and Companies. He is a physicist who got fascinated by the field of aging and longevity and asked the question of why we live as long as we do and no longer. In today's episode, we dive into his research on the scaling laws in biology and longevity. Episode Show Notes: https://livelongerworld.substack.com/p/gwest Find the previous podcast episodes & subscribe to be notified: https://livelongerworld.substack.com/ Find me (Aastha) on Twitter: https://twitter.com/aasthajs DR. GEOFFREY WEST LINKS: Profile: https://www.santafe.edu/people/profile/geoffrey-west Book: https://amzn.to/3Xtl7wU CONNECT WITH AASTHA, LIVE LONGER WORLD: Newsletter: https://livelongerworld.substack.com/ Twitter: https://twitter.com/aasthajs Instagram: https://www.instagram.com/aasthajs/ Airchat: https://www.getairchat.com/aasthajs TIMESTAMPS: 1:35 Context on Dr. West's book Scale 9:00 Networks in biology & cities 22:50 Scaling laws in longevity 32:33 Upper limit to human age? 39:08 Quantifying Caloric restriction 41:52 Metabolism & Body temperature 49:05 Scaling laws in age-related damage 56:35 Scaling body sizes across species 1:01:38 Scaling laws in drug dosage (LSD & Elephants) 1:11:06 Drug dosage in children (Tylenol & babies) 1:13:44 Vaccine dosage scaling laws 1:17:51 Sleep & Aging in different organisms 1:31:22 Early stimulation for child development 1:36:35 Fasting, meal frequency & digestive time 1:39:10 Sleep demands with work & physical activity 1:43:40: Scaling laws in cities, companies & universities 2:02:00 Outro POPULAR EPSIODES: Richard Miller on Longevity Supplements: https://youtu.be/42PzfNs9egA Matt Kaeberlein on Rapamycin: https://youtu.be/BL67DhNepfg Michael Levin on Bioelectric Signals for Longevity: https://youtu.be/XboYI_wxDr8 Nir Barzilai on Metformin & Centenarians: https://youtu.be/YlkBE8N7sl8 Morgan Levine on Epigenetic Clocks: https://youtu.be/am3YKiTpCHo Thanks for watching & if you enjoy the episode, let's spread the message on longevity. You can support my work by sharing, liking, subscribing, leaving a review on Apple podcasts, or signing up as a premium member . Aging is universal. Let's unite in this fight. Stay in good health - Aastha.…
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1 #25 Caloric Restriction Deep-Dive & Longevity Secrets of Long-Lived Animals | Dr. Steven Austad 1:08:36
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Відтворити Пізніше Відтворити Пізніше Списки Подобається ПодобаєтьсяAll platforms / Episode Transcript: https://livelongerworld.substack.com/p/saustad Dr. Steven Austad is a professor in the Healthy Aging department at the University of Alabama and also scientific director of the American Federation for Aging research. He has a fascinating entry into the world of aging research - it all began with training lions! There are many open questions on the caloric restriction research for enhancing longevity and we dive into that. Further, a lot of Dr. Austad’s work focuses on what long-lived animal species can teach us about living longer and healthier lives. His lab works on exotic species, like clams that live more than 500 years, and hydra that don’t age at all, in order to discover aging treatments. He also tries to uncover the mysteries around why men and women respond differently to longevity therapeutics. Find the previous podcast episodes & subscribe to be notified: https://livelongerworld.substack.com/ Find me (Aastha) on Twitter: https://twitter.com/aasthajz DR. STEVEN AUSTAD LINKS: Website: https://www.stevenaustad.com/ Twitter: https://twitter.com/StevenAustad Faculty page: https://www.uab.edu/cas/biology/people/faculty/steven-n-austad CONNECT WITH AASTHA, LIVE LONGER WORLD: Website: https://www.livelongerworld.com/ Twitter: https://twitter.com/aasthajz Newsletter: https://livelongerworld.substack.com/ Instagram: https://www.instagram.com/aasthajz/ TIMESTAMPS: 0:00 Training lions 7:15 Learning from Long-lived species 9:55 Bowhead whales live 200 years 12:55 House sparrows & longevity 14:40 Study "successful" animals 18:10 Naked Mole Rats 20:45 What do bowhead whales die from? 26:05 Why do ocean animals live longest? 31:05 Beyond Caloric Restriction 36:00 Intermittent Fasting & Circadian Rhythm 42:40 Caloric Restriction for Healthy people? 46:24 Will coffee shorten your life? 49:43 The Blue Zone Myth 55:50 Young Blood, I can't get you of out my Mind 1:00:26 Hormones & Health (Growth Hormones for longevity?) 1:05:18 Sex differences in longevity Episode Show Notes: https://livelongerworld.substack.com/p/saustad POPULAR EPSIODES: - Richard Miller on Longevity Supplements: https://youtu.be/42PzfNs9egA - Matt Kaeberlein on Rapamycin: https://youtu.be/BL67DhNepfg - Michael Levin on Bioelectric Signals for Longevity: https://youtu.be/XboYI_wxDr8 - Nir Barzilai on Metformin & Centenarians: https://youtu.be/YlkBE8N7sl8 - Morgan Levine on Epigenetic Clocks: https://youtu.be/am3YKiTpCHo Thanks for watching & if you enjoy the episode, let's spread the message on longevity. You can support my work by sharing, subscribing, leaving a review on Apple podcasts, donating on Patreon, or signing up as a premium member. Aging is universal. Let's unite in this fight. Stay in good health - Aastha.…
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1 #24 Dr. Dominic D'Agostino | Modified Ketogenic Diet for Optimal Health & Exercise (Part 2) 1:09:41
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Відтворити Пізніше Відтворити Пізніше Списки Подобається ПодобаєтьсяAll platforms / Episode Transcript & Timestamps: https://livelongerworld.substack.com/p/dom2 Dr. Dom D’Agostino may require no introduction especially in the world of ketosis! He is an Associate Professor with his research focusing on metabolic therapies, ketogenic diets, ketone supplements, and other metabolic based drugs. He is also a research scientist at the Institute of Human and Machine Cognition. This is Part 2 of a 2 part conversation with Dom. He has so much knowledge to share and in this episode we dive into the ketogenic diet for exercise performance, keto for women & children, Dom's diet & supplement routine + more! Hope you enjoy the episode! Part 1 with Dom on Ketogenic diets for Brain Health and Longevity: https://livelongerworld.substack.com/p/dom1 Find the previous podcast episodes & subscribe to be notified: https://livelongerworld.substack.com/ Find me (Aastha) on Twitter: https://twitter.com/aasthajz SUPPORT LIVE LONGER WORLD: Sign up for Premium Subscriber Transcripts: https://www.livelongerworld.com/premium Patreon: https://www.patreon.com/livelongerworld One-Time support: https://www.paypal.com/paypalme/livelongerworld DOM D'AGOSTINO LINKS: KetoNutrition: https://ketonutrition.org/ Website: https://linktr.ee/Domdagostino Twitter: https://twitter.com/DominicDAgosti2 CONNECT WITH AASTHA, LIVE LONGER WORLD: Website: https://www.livelongerworld.com/ Twitter: https://twitter.com/aasthajz Newsletter: https://livelongerworld.substack.com/ Instagram: https://www.instagram.com/aasthajz/ TIMESTAMPS: 0:00 Ketogenic diet for muscle performance 0:50 Dom’s supplements & modified keto diet 3:20 Keto, NAD+, NMN 7:12 Biomarkers tracked by Dom 9:30 LDL, Triglycerides, Fatty Foods & Keto diet 14:15 Dom’s routine & supplements 18:09 Melatonin benefits for anti-cancer & antioxidant 22:37 Ketogenic diet for women 30:55 Ketogenic diet for children 32:48 Genetic aspect to keto diet? 38:32 Metformin for suppressing cancer 46:30 Ketogenic diet & Alzheimer’s 54:40 Exercise for mental health 55:53 Keto for exercise performance & bodybuilding 59:32 Endogenous metabolite & psychedelics 1:09:05 Connect with me (Aastha) Episode Show Notes: https://livelongerworld.substack.com/p/dom2 Thanks for watching & if you enjoy the episode, let's spread the message on longevity. If you like the podcast, please leave a review on Apple podcasts. Aging is universal. Let's unite in this fight. Stay in good health - Aastha.…
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All platforms / Episode Transcript & Timestamps: https://livelongerworld.substack.com/p/dom1 Dr. Dom D’Agostino may require no introduction especially in the world of ketosis! He is an Associate Professor with his research focusing on metabolic therapies, ketogenic diets, ketone supplements, and other metabolic based drugs. He is also a research scientist at the Institute of Human and Machine Cognition. This is Part 1 of a 2 part conversation with Dom. He has so much knowledge to share and in this episode we dive into the history of ketogenic diets, keto for brain health and neuroprotective seizures, keto for longevity benefits, weight training, caloric restriction and more. Hope you enjoy the episode! Find the previous podcast episodes & subscribe to be notified: https://livelongerworld.substack.com/ Find me (Aastha) on Twitter: https://twitter.com/livelongerworld SUPPORT LIVE LONGER WORLD: Sign up for Premium Subscriber Transcripts: https://www.livelongerworld.com/premium Patreon: https://www.patreon.com/livelongerworld One-Time support: https://www.paypal.com/paypalme/livelongerworld DOM D'AGOSTINO LINKS: KetoNutrition: https://ketonutrition.org/ Website: https://linktr.ee/Domdagostino Twitter: https://twitter.com/DominicDAgosti2 CONNECT WITH AASTHA, LIVE LONGER WORLD: Website: https://www.livelongerworld.com/ Twitter: https://twitter.com/livelongerworld Newsletter: https://livelongerworld.substack.com/ Instagram: https://www.instagram.com/longevityfuture/ TIMESTAMPS: 0:00 Ketogenic diet is not optimal for everyone 0:56 Dom D’Agostino Intro 1:29 Plant-based ketogenic diet 3:20 Ketogenic diet & brain protection against seizures 16:40 Ketone Esters & Salts 19:29 Does the brain need glucose? 21:37 Intermittent Ketosis & Fasting Mimicking Diet 25:17 Cyclic Ketogenic diet for longevity 28:40 Devices for tracking ketosis 30:30 Ketogenic diet for longevity vs. Caloric restriction 37:50 Keto diet for cancer prevention 41:57 Keto diet, Insulin pathway, and glucose 46:50 Time restricted eating benefits 50:17 Dom vs. Layne Norton on Joe Rogan podcast 51:40 Muscle for longevity (especially for women) 56:10 Support Live Longer World Episode Show Notes: https://livelongerworld.substack.com/p/dom1 Thanks for watching & if you enjoy the episode, let's spread the message on longevity. You can support my work by sharing, liking, subscribing, leaving a review on Apple podcasts, donating on Patreon, or signing up as a premium member. Aging is universal. Let's unite in this fight. Stay in good health - Aastha.…
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1 #22 The Cancer Diet Connection & Otto Warburg - Nobel Prize Scientist under Hitler | Sam Apple, Author of Ravenous 1:03:21
1:03:21 Відтворити Пізніше Відтворити Пізніше Списки Подобається Подобається1:03:21
Відтворити Пізніше Відтворити Пізніше Списки Подобається ПодобаєтьсяAll platforms / Episode Show Notes: https://livelongerworld.substack.com/p/sapple Sam Apple is the author of Ravenous: Otto Warburg, The Nazis, and the Search for the Cancer-Diet Connection. Otto Warburg was a Nobel-Prize winning German scientist during the era of Hitler and the Nazi’s and he was the first person to put the metabolic story of cancer on the map. The famous “Warburg Effect” that shows how cancer cells have an increase in glucose uptake even in the presence of oxygen, is named after him. It was a fascinating conversation talking about how the story of cancer research has evolved - how cancer cells eat to the discovery of oncogenes to coming full circle and making the connection between the two, and what the debate still holds in the story. We also talk about how cancer cells take up a lot of glucose, feed on sugar, and the connection between obesity and cancer. I hope you enjoy the conversation! Find the previous podcast episodes & subscribe to be notified: https://livelongerworld.substack.com/ Find me (Aastha) on Twitter: https://twitter.com/livelongerworld SUPPORT LIVE LONGER WORLD: Sign up for Premium Subscriber Transcripts: https://www.livelongerworld.com/premium Patreon: https://www.patreon.com/livelongerworld One-Time support: https://www.paypal.com/paypalme/livelongerworld SAM APPLE LINKS: Ravenous book: https://amzn.to/3yT9qpd Website: http://www.samapple.com/ Twitter: https://twitter.com/Sam_Apple1 CONNECT WITH AASTHA, LIVE LONGER WORLD: Website: https://www.livelongerworld.com/ Twitter: https://twitter.com/livelongerworld Newsletter: https://livelongerworld.substack.com/ Instagram: https://www.instagram.com/longevityfuture/ TIMESTAMPS: 0:00 Cancer as a disease of modern societies 1:27 Otto Warburg & the Cancer-Metabolic Connection 2:27 Warburg’s research on respiration 4:02 Why was cancer skyrocketing in Western societies? 9:17 Warburg Effect: Warburg’s research on cancer cells 15:00 Why do cancer cells take up so much glucose? 17:44 Cancer-Diet Connection 21:44 Cancer, Ketogenic diets & Fasting 23:43 Hibernation of the metabolic story of cancer 27:20 Hitler’s connection with cancer 30:07 Warburg’s arrogance 31:51 Why does cancer need glucose? 38:46 Warburg’s stigma: connecting with Nazi’s 40:51 Is insulin responsible for cancer? 48:00 Science is not immune from politics 50:24 Prostate cancer & obesity 52:13 Pendulum swing in cancer research 54:40 Mitochondria & Cancer Connection 57:07 Nazi’s fixation on cancer Episode Show Notes: https://livelongerworld.substack.com/p/sapple Live Longer World Season 1 Recap: https://livelongerworld.substack.com/p/season1 Thanks for listening & if you enjoy the episode, let's spread the message on longevity. You can support my work by sharing, liking, subscribing, leaving a review on Apple podcasts, donating on Patreon, or signing up as a premium member. Aging is universal. Let's unite in this fight. Stay in good health - Aastha.…
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1 #21 Selenium's Dual Role in Health & Aging in the Womb | Dr. Vadim Gladyshev 1:00:16
1:00:16 Відтворити Пізніше Відтворити Пізніше Списки Подобається Подобається1:00:16
Відтворити Пізніше Відтворити Пізніше Списки Подобається ПодобаєтьсяAll platforms / Episode Show Notes: https://livelongerworld.substack.com/p/vgladyshev Dr. Vadim Gladyshev is a professor at Harvard Medical school and a Director of redox medicine at Brigham and Women’s hospital, where he runs his own lab. We had a brilliant discussion which started off by talking about his work on selenium. Selenium is found is Brazil nuts and we discussed its connection to aging and cancer prevention, and also some of the harmful effects it can have. Dr. Gladyshev calls it the good, the bad, the ugly nature of selenium. Then, we discussed a fair bit on his theory of aging before and after development. Most people believe that the germline which is the reproductive cells do not age, but his lab’s work has shown how the germline does in fact age. On this point, his lab also has interesting results on how rapamycin during development extended lifespan in mice. It’s important to understand the basic science and understand more on the aging process in order to crack it. Dr. Gladyshev shares his views on this too and his research is certainly a step towards cracking the aging code. I hope you enjoy the conversation! Find the previous podcast episodes & subscribe to be notified: https://www.livelongerworld.com/podcast Sign up for Premium Subscriber Transcripts: https://www.livelongerworld.com/premium Support on Patreon: https://www.patreon.com/livelongerworldOne-Time support: https://www.paypal.com/paypalme/livelongerworld Find me on Twitter: https://twitter.com/livelongerworld VADIM GLADYSHEV LINKS: Website: https://gladyshevlab.bwh.harvard.edu/2022 Rapamycin During Development extends Lifespan: https://www.biorxiv.org/content/10.1101/2022.02.18.481092v1 LIVE LONGER WORLD LINKS: Website: https://www.livelongerworld.com/ Twitter: https://twitter.com/livelongerworld Newsletter: https://livelongerworld.substack.com/ Instagram: https://www.instagram.com/longevityfuture/ Patreon: https://www.patreon.com/livelongerworld YouTube: https://www.youtube.com/c/LiveLongerWorld Premium Subscriber: https://www.livelongerworld.com/premium TIMESTAMPS: 0:00 Vadim Gladyshev Intro 1:28 Live Longer World 2:17 Selenium’s dual role in aging (the good, the bad, the ugly) 11:27 Antagonistic Pleiotropy 13:53 Selenium & Cancer 15:58 Selenium Dosage (don’t get too much!) 18:30 Reactive Oxygen Species, Antioxidants & Aging 22:30 Fundamental basis of Aging 24:09 Aging is damage 29:20 Single cell Epigenetic Clocks 34:22 Aging in the Womb 42:16 Parent’s lifestyle for aging in embryo 44:14 Rapamycin during development 49:06 Other compounds 51:53 Slowing Aging vs. Rejuvenation 56:08 New projects being worked on 57:17 Confidence level in extending lifespan within 30 years 59:17 Support Live Longer World Episode Show Notes: https://livelongerworld.substack.com/p/vgladyshev Live Longer World Season 1 Recap: https://livelongerworld.substack.com/p/season1 Thanks for watching & if you enjoy the episode, let's spread the message on longevity. You can support my work by sharing, liking, subscribing, leaving a review on Apple podcasts, donating on Patreon, or signing up as a premium member. Aging is universal. Let's unite in this fight. Stay in good health - Aastha.…
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1 #20 Cardiovascular Disease Risk Assessment & Ketogenic Diets for Heart Health | Dr. Ethan Weiss 1:11:50
1:11:50 Відтворити Пізніше Відтворити Пізніше Списки Подобається Подобається1:11:50
Відтворити Пізніше Відтворити Пізніше Списки Подобається ПодобаєтьсяDr. Ethan Weiss is a cardiologist and his special interests include preventive cardiology, genetics of coronary disease, risk assessment, and heart disease in the young. In today’s conversation we spoke about misconceptions people have about heart disease, genetic factors involved in heart disease, how to understand cholesterol and triglycerides in the context of heart disease, ketogenic diets for preventative cardiology and so much more. If you want to understand how to think about your risk assessment for cardiovascular disease and how to prevent it, this conversation is for you. All platforms / Episode Show Notes: https://livelongerworld.substack.com/p/eweiss Find the previous podcast episodes & subscribe to be notified: https://www.livelongerworld.com/podcast Sign up for Premium Subscriber Transcripts: https://www.livelongerworld.com/premium Support on Patreon: https://www.patreon.com/livelongerworld One-Time support: https://www.paypal.com/paypalme/livelongerworld ETHAN WEISS LINKS: Website: https://profiles.ucsf.edu/ethan.weiss Twitter: https://twitter.com/ethanjweiss LIVE LONGER WORLD LINKS: Website: https://www.livelongerworld.com/ Twitter: https://twitter.com/livelongerworld Newsletter: https://livelongerworld.substack.com/ Instagram: https://www.instagram.com/longevityfuture/ Patreon: https://www.patreon.com/livelongerworld YouTube: https://www.youtube.com/c/LiveLongerWorld Premium Subscriber: https://www.livelongerworld.com/premium TIMESTAMPS: 0:00 Welcome to Live Longer World 0:44 Misconceptions of heart disease / young people with heart disease 4:01 Predictors of heart disease 6:59 LDL vs HDL; Triglycerides 12:51 Small-dense LDL vs. Large fluffy LDL 16:09 Dietary Carbohydrates & heart disease risk 25:50 Inflammation & Cardiovascular risk 26:43 Lipoproteins, ApoB, Lp(a) 31:31 Statins, PCSK9 inhibitors 32:45 ApoB as gold standard risk marker 36:50 Triglycerides & Insulin resistance 40:00 Saturated Fat 42:42 Variation in Cholesterol measurement 46:03 Body composition as marker for heart disease risk 51:23 Ketogenic diets & heart health 56:43 Keyto breath sensor 1:01:46 Stress & heart disease 1:04:44 Growth hormone & heart disease 1:07:46 On the shortness of life 1:10:52 Support & Connect with Live Longer World Episode Show Notes: https://livelongerworld.substack.com/p/eweiss Live Longer World Season 1 Recap: https://livelongerworld.substack.com/p/season1 Thanks for listening & if you enjoy the episode, let's spread the message on longevity. Aging is universal. Let's unite in this fight. Stay in good health - Aastha.…
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1 #19 Michael Levin | Can Bioelectrical Signals Reverse Aging? 1:00:27
1:00:27 Відтворити Пізніше Відтворити Пізніше Списки Подобається Подобається1:00:27
Відтворити Пізніше Відтворити Пізніше Списки Подобається ПодобаєтьсяDr. Michael Levin is an American developmental and synthetic biologist at Tufts University where he heads his own lab. He also directs the Tufts Center for Regenerative and Developmental Biology. His groundbreaking research focuses on bioelectrical signals that dictate the collective intelligence of cells and direct it to form tissues and organs. His work on bioelectric signals has important applications for how we understand cancer, regenerative medicine and even aging. In fact, he is collaborating with David Sinclair to see how his work can be applied to reverse aging. Michael Levin’s work is fascinating and will surely leave you thinking. I hope you enjoy the conversation! All platforms / Episode Show Notes: https://livelongerworld.substack.com/p/mlevin Find the previous podcast episodes & subscribe to be notified: https://www.livelongerworld.com/podcast Sign up for Premium Subscriber Summarized Show Notes on Key Points: https://www.livelongerworld.com/premium Support on Patreon: https://www.patreon.com/livelongerworld One-Time support: https://www.paypal.com/paypalme/livelongerworld MICHAEL LEVIN LINKS: Website: https://ase.tufts.edu/biology/labs/levin/ Twitter: https://twitter.com/drmichaellevin LIVE LONGER WORLD LINKS: Website: https://www.livelongerworld.com/ Twitter: https://twitter.com/livelongerworld Newsletter: https://livelongerworld.substack.com/ Instagram: https://www.instagram.com/longevityfuture/Patreon: https://www.patreon.com/livelongerworld YouTube: https://www.youtube.com/c/ Live Longer World Premium Subscriber: https://www.livelongerworld.com/premium TIMESTAMPS: 0:40 How do cells decide what to build? 10:05 DNA is insufficient for dictating collective intelligence of cells 19:00 Anatomical Complier (End game) 22:24 History of Cellular Collective Intelligence & Ala Turing 26:30 Regenerative Medicine & Morphoceuticals 38:05 Cells forming new anatomies 44:5 3 Cancer as a morphogenetic problem 55:16 David Sinclair, Bioelectrics to reverse aging 57:44 Synthetic Wombs & Artificial Life 59:41 Support Live Longer World! Episode Show Notes: https://livelongerworld.substack.com/p/mlevin Live Longer World Season 1 Recap: https://livelongerworld.substack.com/p/season1 If you enjoy my work and wish to support it, consider sharing it with a friend or two and leaving a review on Apple podcasts . And if you are further inclined to show love and support, you can donate on Patreon : patreon.com/livelongerworld Thanks for watching & if you enjoy the episode, let's spread the message on longevity. Aging is universal. Let's unite in this fight. Stay in good health - Aastha.…
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1 #18 Longevity Supplements - Interventions Testing Program Results | Dr. Richard Miller 1:21:40
1:21:40 Відтворити Пізніше Відтворити Пізніше Списки Подобається Подобається1:21:40
Відтворити Пізніше Відтворити Пізніше Списки Подобається ПодобаєтьсяDr. Richard Miller runs one of the labs for the Interventions Testing Program or the ITP, which is largely considered the gold standard for testing longevity drugs. This was one of the best conversations I’ve had on longevity supplements that affect lifespan and those that might me subject to mere hype. Dr. Miller is rigorous in his approach and states the data clearly. He also has opinions on lifespan vs. healthspan that are unique from those of most others and worth paying attention to. I genuinely walked away having learned so much from this conversation and feeling more awakened, and I hope it is useful to you too in parsing the data out there on longevity supplements. In today’s episode, you will learn: - The 4 winning drugs that increase lifespan in mice as tested by the ITP: Rapamycin, Acarbose, 17-alpha estradiol, Canagliflozin - 3 other drugs that produce small lifespan benefits: NDGA, Glycine, Captopril - Drug combinations: Rapamycin + Acarbose, Rapamycin + Metformin - Drugs that show no lifespan increase in mice in the ITP: Resveratrol, Nicotinamide-Riboside (NR), Fisetin, Curcumin, MCT Oil, Green tea extract, Fish Oil + more - Richard’s thoughts on lifespan vs. healthspan All platforms / Episode Show Notes / Timestamps: https://livelongerworld.substack.com/p/rmiller Find the previous podcast episodes & subscribe to be notified: https://www.livelongerworld.com/podcast Sign up for Premium Subscriber Summarized Show Notes: https://www.livelongerworld.com/premium Support on Patreon: https://www.patreon.com/livelongerworld One-Time support: https://www.paypal.com/paypalme/livelongerworld RICHARD MILLER LINKS: Website: http://www.richmillerlab.com/ Photography: https://richardmiller.zenfolio.com/ Interventions Testing Program: https://www.nia.nih.gov/research/dab/interventions-testing-program-itp LIVE LONGER WORLD LINKS: Website: https://www.livelongerworld.com/ Twitter: https://twitter.com/livelongerworld Newsletter: https://livelongerworld.substack.com/ Instagram: https://www.instagram.com/longevityfuture/ Patreon: https://www.patreon.com/livelongerworld YouTube: https://www.youtube.com/c/LiveLongerWorld Premium Subscriber: https://www.livelongerworld.com/premium TIMESTAMPS: 0:55 Richard Miller Intro 1:51 Richard Miller Wildlife photography 3:30 ITP - the gold standard for testing longevity drugs & winning drugs 10:51 Rapamycin, Rapamycin + Acarbose 18:48 Rapamycin + Acarbose Dosing Schedule 20:15 Combination of drugs, Rapamycin + Metformin 21:56 17-Alpha Estradiol 25:45 Canagaflozin 31:34 Does Richard take the 4 winning drugs? 32:46 3 Drugs that have small lifespan effects & promising 36:30 GPLD-1 & shared mechanisms in longevity drugs 44:04 Resveratrol in ITP 46:27 NR, NMN 52:34 Curcumin, Green Tea Extract, MCT Oil 54:54 Fisetin & Senolytics 56:12 Why most published research findings are false 1:00:03 Healthspan biomarkers at the ITP 1:02:38 Can you have healthspan without lifespan? 1:07:37 Fish Oil, Spermidine, Sulforophane 1:12:13 Unpublished data Richard is excited about 1:17:47 Flying Pigs & Aubrey De Grey 1:20:00 Exponential rise in aging research Episode Show Notes: https://livelongerworld.substack.com/p/rmiller Thanks for listening & if you enjoy the episode, let's spread the message on longevity. You can leave a review on Apple podcasts, subscribe and share the podcast. Aging is universal. Let's unite in this fight.…
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1 #17 Epigenetic Reprogramming, Yamanaka Factors, Cryonics & COVID Lab Leak | Yuri Deigin 1:02:51
1:02:51 Відтворити Пізніше Відтворити Пізніше Списки Подобається Подобається1:02:51
Відтворити Пізніше Відтворити Пізніше Списки Подобається ПодобаєтьсяYuri Deigin is the founder and CEO of YouthBio Therapeutics which is a company that is working on Epigenetic reprogramming or using the Yamanka factors to achieve partial reprogramming. Epigenetic reprogramming has been in the news lately because of several companies being started in the space, with some notable ones being Altos Labs funded by Jeff Bezos and NewLimit founded by Brian Armstrong, CEO of Coinbase. If you’re not familiar with this trending, hyped (rightly so this time - it is pretty amazing!) research on Epigenetic reprogramming and Yamanaka factors to turn cells back to a younger state, we dive into it in today’s episode! As a last point to Yuri’s introduction, because I’d be remiss if I didn’t mention it, you may have heard of his name recently because he was in fact one of the first people to talk about the COVID lab leak theory and wrote extensively on it. This speaks to his scientific mindset and desire to uncover the truth. In today’s episode, you will learn: - The Strong Epigenetic Theory of Aging, as coined by Yuri (He calls David Sinclair’s theory The Weak Epigenetic Theory of Aging) - Epigenetic Reprogramming using Yamanaka factors to turn the cell into a younger state - What is it and what are the open questions in the field - What are the cancer risks associated with it - Why Yuri believes in Cryonics - Why Yuri got interested in uncovering the COVID-19 Lab Leak theory - Pharma in Russia If you are a premium subscriber, you can also read the summarized notes of these learnings in the show notes. All platforms / Episode Show Notes: https://livelongerworld.substack.com/p/ydeigin Find the previous podcast episodes & subscribe to be notified: https://www.livelongerworld.com/podcast Sign up for Premium Subscriber Summarized Show Notes on Key Points: https://www.livelongerworld.com/premium Support on Patreon: https://www.patreon.com/livelongerworld One-Time support: https://www.paypal.com/paypalme/livelongerworld YURI DEIGIN LINKS: Twitter: https://twitter.com/ydeigin LinkedIn: https://www.linkedin.com/in/yurideigin/ Medium: https://yurideigin.medium.com/ YouthBio Therapeutics: https://youthbiotx.com/ LIVE LONGER WORLD LINKS: Website: https://www.livelongerworld.com/ Twitter: https://twitter.com/livelongerworld Newsletter: https://livelongerworld.substack.com/ Instagram: https://www.instagram.com/longevityfuture/ Patreon: https://www.patreon.com/livelongerworld YouTube: https://www.youtube.com/c/LiveLongerWorld Premium Subscriber: https://www.livelongerworld.com/premium TIMESTAMPS: 00:00 "We're not crazy" 0:37 100% life extension & translation to humans 4:28 Aging is potentially an engineering problem 12:45 Strong Epigenetic Theory of Aging 19:26 Epigenetic Reprogramming 29:00 Risk of Cancer with Epigenetic reprogramming 33:00 Rejuvenation without cancer risk? 38:30 Why Cryonics Makes Sense 48:00 COVID Lab Leak Theory 53:45 Pharma in Russia 58:40 Optimism in Longevity 1:00:50 Aging is Universal. Let's Unite in this Fight Episode Show Notes: https://livelongerworld.substack.com/p/ydeigin Thanks for listening & if you enjoy the episode, let's spread the message on longevity. You can leave a review on Apple podcasts, subscribe and share the podcast. Aging is universal. Let's unite in this fight. Stay in good health - Aastha.…
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1 #16 Cancer, Cellular Senescence & Senolytics | Dr. Peter Adams 1:09:30
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Відтворити Пізніше Відтворити Пізніше Списки Подобається ПодобаєтьсяDr. Peter Adams , Professor at Sanford Burnham Prebys Medical Discovery Institute, is an expert in the biology of aging and cancer. The Peter Adams Lab is focused on the Epigenetics of Cancer & Aging and their goal is to contribute to development of epigenetic-based interventions that promote healthy aging and suppression of disease, including cancer. You will hear about some of these contributions in this conversation. In today’s episode, you will learn: Cellular Senescence and it’s dual role in protecting against cancer but also causing tissue aging The role of senolytic drugs to protect against age-associated cellular senesence The connection between the mitochondria and cellular senescence The Developmental theory of aging (Aging begins in the womb!) If you are a premium subscriber , you can also read the summarized notes of these learnings in the show notes. All platforms / Episode Show Notes: https://livelongerworld.substack.com/p/padams Find the previous podcast episodes & subscribe to be notified: https://www.livelongerworld.com/podcast Sign up for Premium Subscriber Summarized Show Notes on Key Points: https://www.livelongerworld.com/premium Support on Patreon: https://www.patreon.com/livelongerworld One-Time support: https://www.paypal.com/paypalme/livelongerworld PETER ADAMS LINKS: Lab Website & Bio: http://www.padamslab.org/pages/members.html Peter Adams Twitter: https://twitter.com/AdamsBioAging Peter's Recent Publications: https://www.sbpdiscovery.org/our-scientists/peter-d-adams-phd LIVE LONGER WORLD LINKS: Website: https://www.livelongerworld.com/ Twitter: https://twitter.com/livelongerworld Newsletter: https://livelongerworld.substack.com/ Instagram: https://www.instagram.com/longevityfuture/ Patreon: https://www.patreon.com/livelongerworld YouTube: https://www.youtube.com/c/LiveLongerWorld Premium Subscriber: https://www.livelongerworld.com/premium TIMESTAMPS & EPISODE SHOW NOTES: https://livelongerworld.substack.com/p/padams Thanks for listening & if you enjoy the episode, let's spread the message on longevity. Aging is universal. Let's unite in this fight. Stay in good health - Aastha.…
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My guest today is Andy Lee who is the Chief Operating Officer at Vincere Biosciences. Vincere is working to stop Parkinson’s disease by creating small molecules or drugs that target mitochondrial dysfunction. There is increasing evidence that a dysfunctional mitochondria can lead to the onset of Parkinson’s disease. In today’s conversation, we discussed the science behind a dysfunctional mitochondria and mitophagy, the relationship between the mitochondria and Parkinson’s disease, and whether certain mitochondria boosting supplements like Urolithin A and Coq10 that delay the onset of Parkinson’s. We also discussed the biological simulation and computational biology platform used by Vincere - they use AI systems that can be used to screen drugs & targets and simulate cell environments. Finally, we spoke about the challenges with running a biotech company. Andy comes from a background in technology and computer science background and he combined it with biology to create Vincere Biosciences. All platforms / Episode Show Notes: https://livelongerworld.substack.com/p/alee Find the previous podcast episodes & subscribe to be notified: https://www.livelongerworld.com/podcast Sign up for Premium Subscriber Summarized Show Notes on Key Points: https://www.livelongerworld.com/premium Support on Patreon: https://www.patreon.com/livelongerworld One-Time support: https://www.paypal.com/paypalme/livelongerworld ANDY LEE / VINCERE BIO LINKS: Vincere Website: https://vincerebio.com/ Andy Lee Twitter: https://twitter.com/andy_d_lee LIVE LONGER WORLD LINKS: Website: https://www.livelongerworld.com/ Twitter: https://twitter.com/livelongerworld Newsletter: https://livelongerworld.substack.com/ Instagram: https://www.instagram.com/longevityfuture/ Patreon page: https://www.patreon.com/livelongerworld Podcast All Platforms: https://anchor.fm/livelongerworld YouTube: https://www.youtube.com/c/LiveLongerWorld Apple Podcasts: https://apple.co/3eZAoAp Spotify: https://spoti.fi/3eZB6O5 Google Podcasts: https://bit.ly/3HN0keG Premium Subscriber Benefits: https://www.livelongerworld.com/premium TIMESTAMPS: 0:00 Live Longer World Intro 0:34 Andy Lee & Vincere Bio Intro 1:55 Vincere & the connection between mitochondria & Parkinson's 7:39 Mitophagy & Parkinson’s disease 16:29 Role of USP30 in Mitochondria & Parkinson’s 22:26 Vincere small molecules testing 25:18 Other pathways affected during Parkinson's 30:53 Computation Biology Platform used by Vincere 36:50 Urolithin A & Coq10 to help with Parkinson’s 39:45 Biomarkers for Mitophagy 42:46 Too much mitophagy? 44:50 Challenges running a biotech company 48:19 Path forward for Vincere 49:36 Support, share and follow Live Longer World! Want Summarized Notes on Key Points Discussed in the Podcast? Gain access by signing up as a premium subscriber. Your contribution supports my work and the advancement of longevity science! Key points summarized in the show notes for premium subscribers include: 1. The connection between Mitochondrial quality control & Parkinson’s disease 2. Mitophagy and the science behind targeting the mitochondria 3. Overview of the Biological Simulation Platform used by Vincere Bio 4. Can compounds like Urolithin A & Coq10 that target the mitochondria delay Parkinson’s 5. Challenges with running a Biotech Co. Learn more on Premium Subscriber Benefits: https://www.livelongerworld.com/premium Ep. Show notes: https://livelongerworld.substack.com/p/alee…
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Live Longer World
1 #14 Dr. Bjorn Schumacher | DNA Damage & Aging, p53 & Cancer, and DNA repair in Reproductive Cells 55:48
My guest today is Dr. Bjorn Schumacher whose work focuses on the central role of DNA damage in the aging process. We discussed DNA damage accumulation with age, how DNA repair mechanisms play a role, how DNA damage in the reproductive cells can tell us a lot about aging, human fertility and reproductive capacity. We also discussed the role of p53 in cancer suppression, a new biological age clock being developed in his lab and how we should protect our skin from aging and thereby control DNA damage. A lot of us have heard about the link between DNA damage and aging and this conversation really dives into it. All platforms / Episode Show Notes: https://livelongerworld.substack.com/p/bschumacher Find the previous podcast episodes & subscribe to be notified: https://www.livelongerworld.com/podcast Sign up for Premium Subscriber Summarized Show Notes on Key Points: https://www.livelongerworld.com/premium Support on Patreon: https://www.patreon.com/livelongerworld One-Time support: https://www.paypal.com/paypalme/livelongerworld DR. BJORN SCHUMACHER LINKS: Lab Website: https://www.cecad.uni-koeln.de/research/principal-investigators/prof-dr-bjoern-schumacher Twitter: https://twitter.com/schumacherbj Author of the book: The Mysteries of Human Aging: Surprising Insights from a Science That's Still Young: https://amzn.to/3LyR3JU LIVE LONGER WORLD LINKS: Website: https://www.livelongerworld.com/ Twitter: https://twitter.com/livelongerworld Newsletter: https://livelongerworld.substack.com/ Instagram: https://www.instagram.com/longevityfuture/ Patreon page: https://www.patreon.com/livelongerworld Podcast All Platforms: https://anchor.fm/livelongerworld YouTube: https://www.youtube.com/c/LiveLongerWorld Apple Podcasts: https://apple.co/3eZAoAp Spotify: https://spoti.fi/3eZB6O5 Google Podcasts: https://bit.ly/3HN0keG Premium Subscriber Benefits: https://www.livelongerworld.com/premium TIMESTAMPS: 0:00 Live Longer World Intro 0:30 Bjorn Schumacher Intro 1:22 DNA Damage as Central to the Aging process 3:37 DNA repair with age 8:39 Premature aging; 2 distinct forms of DNA damage 14:15 How does an aging human survive with DNA damage & tamp down cancer? 18:20 Stress to reproductive cells builds up immunity in the body 24:41 Female reproduction, Menopause & DNA repair 27:46 p53 and it’s role in DNA repair 35:13 BiT Clock: New Biological Age Clock 43:59 Skin Aging and DNA damage 48:06 Stress in the intestine / gut can alter the chromosome 53:00 Germ cells are immortal For links to DR. Bjorn Schumacher research discussed: https://livelongerworld.substack.com/p/bschumacher Want Summarized Notes on Key Points Discussed in the Podcast? Gain access by signing up as a premium subscriber . Your contribution supports my work the advancement of longevity science! Key points summarized in the show notes for premium subscribers include: The central role of DNA damage in the aging process What happens to our body’s DNA repair mechanism with age? DNA Damage in the germ cells (reproductive cells) promotes stress resistance in the body The role of p53 in suppressing cancer and in the DNA repair process Learn more: https://www.livelongerworld.com/premium Thanks for listeni…
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Live Longer World
1 #13 Dr. David Gems | Hyperfunction & Programmatic Theory of Aging and Critique of the Hallmarks of Aging 1:24:58
1:24:58 Відтворити Пізніше Відтворити Пізніше Списки Подобається Подобається1:24:58
Відтворити Пізніше Відтворити Пізніше Списки Подобається ПодобаєтьсяMy guest today is Dr. David Gems who runs the C. Elegans Aging lab at the University College London. We had a fascinating discussion talking about emerging paradigms in the theories of aging. We discussed the hyperfunction theory or the programmatic theory of aging which gives a better integrated understanding of the different theories of aging that have been presented such as damage accumulation, evolutionary, antagonistic pleiotropy. It has been assumed that molecular damage is always the cause of aging, but the programmatic theory of aging shows that that might not be the case. We also discussed his critique of the hallmarks of aging and how there should be a better paradigm for the aging field. Lastly, we also discussed how research from his lab on C. Elegans might explain some of the conflict around whether sirtuins affect lifespan and how C. Elegans also show versions of this programmatic theory of aging, which can give us a better understanding of how to study aging. Note: There is a point in the conversation (40:41) where David pulls up some slides to better explain the Multifactorial Model of Aging. So if you are listening to the audio version, you might want to refer to YouTube or the show notes . All platforms / Episode Show Notes: https://livelongerworld.substack.com/p/dgems Support on Patreon: https://www.patreon.com/livelongerworld Find the previous podcast episodes & subscribe to be notified: https://www.livelongerworld.com/podcast DR. DAVID GEMS LINKS: Lab Website: https://www.ucl.ac.uk/~ucbtdag/DGHistory.html LIVE LONGER WORLD LINKS: Website: https://www.livelongerworld.com/ Twitter: https://twitter.com/livelongerworld Newsletter: https://livelongerworld.substack.com/ Instagram: https://www.instagram.com/longevityfuture/ Patreon page: https://www.patreon.com/livelongerworld Podcast All Platforms: https://anchor.fm/livelongerworld YouTube: https://www.youtube.com/c/LiveLongerWorld Apple Podcasts: https://apple.co/3eZAoAp Spotify: https://spoti.fi/3eZB6O5 Google Podcasts: https://bit.ly/3HN0keG Premium Subscriber Benefits: https://www.livelongerworld.com/premium TIMESTAMPS: 00:00 Live Longer World 00:25 David Gems Intro 1:47 History of the theories of aging 12:23 Hyperfunction / Programmatic Theory of Aging 24:57 Programmatic Theory of Aging in C. Elegans 36:59 Hyperfunction theory of Aging in Humans 40:41 Multifactorial Model of Aging 50:32 Mutation in C. Elegans affecting Sirtuin research? 59:57 Sirtuin research in humans & conflicting sirtuin research 1:04:44 Metformin affects the gut microbiome 1:07:41 Critique of the Hallmarks of Aging 1:16:12 Disruption in Early Life could lead to Aging related diseases 1:24:23 Support, share, and follow Live Longer World To find links to David Gems research discussed, please refer to the show notes: https://livelongerworld.substack.com/p/dgems Thanks for listening & if you enjoy the episode, please leave a review on Apple podcasts, support on Patreon, subscribe & share! Stay in good health - Aastha.…
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Live Longer World
1 #12 Dr. Bruce Ames | Longevity Micronutrients, Triage Theory, and Vitamin D for Healthy Aging 27:43
My guest today is Dr. Bruce Ames who has received several awards and accolades for developing the Ames test which is used to detect carcinogens in commercial products. He showed how there were carcinogens in products such as hair dyes and children’s pajamas! Later, Dr. Bruce Ames turned to studying micronutrients and how deficiency of important vitamins and minerals leads to accelerated aging. He came up with the Micronutrient triage theory, which says that when nutrient intake is insufficient, the body has a rationing mechanism and favors proteins needed for immediate survival at the expense of protection against future damage. Dr. Bruce Ames is 93 years old and says that he is still exercising and eating healthy greens cooked by his lovely Italian wife! However, he says his cognitive capacity has slowed down (this is why we need rejuvenation therapies, even for the brain: listen to my episode with Dr. Jean Hebert who talks about Brain Aging and his strategy to reverse aging through replacement of the body parts: https://youtu.be/oerGUepWsH8). I am grateful that I had a chance to converse with him on Vitamin D, longevity micronutrients, how micronutrient deficiency can lead to accelerated aging, his take on the science behind reversing aging, and his advice to younger people. This is a shorter episode and I hope you learn more about the importance of micronutrients! All platforms / Episode Show Notes: https://livelongerworld.substack.com/p/bames RELATED WRITING: My newsletter post explaining the Micronutrient Triage theory: https://livelongerworld.substack.com/p/bruceames My post on Longevity Foods (Nutrition Doesn't have to be so complicated): https://livelongerworld.substack.com/p/longevityfoods Sign up for Premium Subscriber Extensive Show Notes & Transcripts: https://www.livelongerworld.com/premium Find the previous podcast episodes & subscribe to be notified: https://www.livelongerworld.com/podcast Find me on Twitter: https://twitter.com/livelongerworld Support on Patreon: https://www.patreon.com/livelongerworld DR. BRUCE AMES LINKS: Website: http://www.bruceames.org/ LIVE LONGER WORLD LINKS: Website: https://www.livelongerworld.com/ Twitter: https://twitter.com/livelongerworld Newsletter: https://livelongerworld.substack.com/ Instagram: https://www.instagram.com/longevityfuture/ Patreon page: https://www.patreon.com/livelongerworld Podcast All Platforms: https://anchor.fm/livelongerworld YouTube: https://www.youtube.com/c/LiveLongerWorld Apple Podcasts: https://apple.co/3eZAoAp Spotify: https://spoti.fi/3eZB6O5 Google Podcasts: https://bit.ly/3HN0keG Premium Subscriber Benefits: https://www.livelongerworld.com/premium TIMESTAMPS: 00:00 Live Longer World 00:36 Bruce Ames Intro 1:50 Micronutrient triage theory 5:40 Micronutrient deficiencies & age acceleration 9:10 Vitamin D for healthy aging 12:26 CHORI Bar 14:46 Measuring micronutrients (blood finger-prick) 16:55 Bruce Ames diet 18:19 Asthma caused by obesity / bad diet improved by CHORI bar 21:21 Dr. Ames lifestyle over the years 22:47 Importance of zinc 24:15 Nutrition is complicated 24:44 Dr. Ames last words & advice for young scientists Thanks for listening & if you enjoy the episode, please like, leave a review on Apple podcasts, subscribe & share! Stay in good health - Aastha.…
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