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PhageLine unpacks the science of bacteriophages, one paper at a time. From groundbreaking studies to surprising discoveries, we translate complex research into engaging conversations. Whether you are steeped in microbiology or just discovering the fascinating world of phages, PhageLine delivers a unique perspective on the science behind these bacterial predators. PhageLine is on BlueSky. Follow us never to miss anything again. This podcast is generated using artificial intelligence. Infectio ...
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The Phage Therapy Today is the pod dedicated to leaders in the phage therapy industry. We bring you insights into current advancements and challenges in this exciting sector from academia, financial, regulatory, manufacturing and entrepreneurial perspectives. Each episode features accomplished guests serving various roles in developing our bacteriophage-evolved community. If you are a believer in the future shaped by phage therapy and want to share you exciting work with our community, email ...
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Hello and welcome to PhageLine - your line to everything phage. This week, we will discuss the effect of an antibiotic and a probiotic on phage communities in swine gut microbiota as featured in a recent paper by Lemieux et al. in BMC Research Notes. Have fun! This episode was generated using artificial intelligence.…
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Hello and welcome to PhageLine - your line to everything phage. This week, we will discuss Vitamin B12 release through bacteriophage-mediated cell lysis of a marine bacterium as featured in a recent paper by Sultana et al. in ISME Communications. Have fun! This episode was generated using artificial intelligence.…
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Hello and welcome to PhageLine - your line to everything phage. This week, we will discuss the synergistic effect of bacteriophages and fusidic acid against meticillin-resistant Staphylococcus pseudintermedius in an ex vivo canine dermis model as featured in a recent paper by Ehling et al. in Veterinary Dermatology. Have fun! This episode was gene…
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Hello and welcome to PhageLine - your line to everything phage. This week, we will discuss Bacteriophage immunotherapy with artificial antigen-directed immune labeling, as presented in a recent paper by Yao et al. in Science Advances. Have fun! This episode was generated using artificial intelligence.…
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PhageLine #28: A Beginner’s Guide to Viral Diversity
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Hello and welcome to PhageLine - your line to everything phage. This week, we will discuss Phage quest: a beginner’s guide to explore viral diversity in the prokaryotic world which is a recent paper by Wendling et al. in Briefings in Bioinformatics. Have fun! This episode was generated using artificial intelligence.…
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Hello and welcome to PhageLine - your line to everything phage. This week, we will discuss the anti-restriction functions of injected phage proteins, as presented in a recent paper by Silas et al. in Nature Communications. Have fun! This episode was generated using artificial intelligence.Planomicrobium massiliensis
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Hello and welcome to PhageLine - your line to everything phage. This week, we will discuss the in vitro and in vivo selection and cost of bacteriophage resistance on natural Escherichia coli, as presented in a recent paper by Cardoso et al. in FEMS microLife. Have fun! This episode was generated using artificial intelligence.…
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Hello and welcome to PhageLine - your line to everything phage This week, we will discuss the efficacy of sequential phage-colistin therapy against carbapenem-resistant Acinetobacter baumannii to overcome phage resistance, as presented in a recent paper by Choi et al. in Microbiology Spectrum. Have fun! This episode was generated using artificial i…
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Hello and welcome to PhageLine - your line to everything phage. This week, we will discuss a hydrogel with physically entrapped phages to control Pseudomonas aeruginosa infections in burn wound models, as presented in a recent paper by Walji et al. in Biomaterials Advances. Have fun! This episode was generated using artificial intelligence.…
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Hello and welcome to PhageLine - your line to everything phage. This week, we will discuss a bacteriophage‑based virus‑like particle vaccine that induces cross‑reactive neutralising antibodies against porcine epidemic diarrhoea viruses (PEDV) by talking about a recent paper from Gu et al in Veterinary Research. Have fun! This episode was generated …
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Hello and welcome to PhageLine - your line to everything phage. This week, we will discuss Phage-antibiotic synergy to combat multidrug-resistant strains of Gram-negative ESKAPE pathogens by examining a recent paper by Morris et al. in Scientific Reports. Have fun! This episode was generated using artificial intelligence. An infectious disease rese…
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Hello and welcome to PhageLine - your line to everything phage. This week, we will discuss the impact of microplastics on bacteriophage activity in aqueous environments by talking about a recent paper from Ochirbat et al. in the Journal of Physical Chemistry. Have fun! This episode was generated using artificial intelligence. An infectious disease …
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Hello and welcome to PhageLine - your line to everything phage. This week, we will discuss the bacteriophage potential of SARS-CoV-2 in human gut microbiota by talking about a recent paper by Petrillo et al in F1000. Have fun! This episode was generated using artificial intelligence. An infectious disease researcher reviewed the episode's contents.…
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Hello and welcome to PhageLine - your line to everything phage. This week, we will discuss a method for the targeted discovery of bacteriophages by co-culture, called Phage DisCo, which was recently published in mSystems by Eleanor Rand and her colleagues at Harvard University. Usually, I would say "have fun" here; however, there is also a dark sid…
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Hello and welcome to PhageLine - your line to everything phage. This week, we will discuss the in vitro genomic characterization and pre-clinical evaluation of a new thermostable lytic Obolenskvirus phage formulated as a hydrogel against carbapenem-resistant Acinetobacter baumannii by discussing a recent paper by Sherif et al. in Scientific Reports…
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Hello and welcome to PhageLine - your line to everything phage. This week, we will discuss personalized inhaled bacteriophage therapy for treating multidrug-resistant Pseudomonas aeruginosa in cystic fibrosis by talking about a recent publication by Chan et al in Nature Medicine. Have fun! This episode was generated using artificial intelligence. A…
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Hello and welcome to PhageLine - your line to everything phage. This week, we will discuss the effects of Phage–phage competition and biofilms on interactions between two virulent bacteriophages and Pseudomonas aeruginosa, which were recently published by Bürkle et al. in ISME. Have fun! This episode was generated using artificial intelligence. An …
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Hello and welcome to PhageLine - your line to everything phage. This week, we will discuss PhageDPO, a machine-learning-based computational framework for identifying phage depolymerases, recently published by Viera et al. in Elsevier's Computers in Biology and Medicine. Have fun! This episode was generated using artificial intelligence. An infectio…
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Hello and welcome to PhageLine - your line to everything phage. This week, we will focus on the differences in phage recognition and immunogenicity in humans unraveled in a recent paper by Le et al. in the European Journal of Immunology. Have fun! This episode was generated using artificial intelligence. An infectious disease researcher reviewed th…
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PhageLine #13: Optimizing Bacteriophage Engineering Through an Accelerated Evolution Platform
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Hello and welcome to PhageLine - your line to everything phage. This week, we will focus on optimizing phage engineering through an accelerated evolution platform by discussing a recent paper by Favor et al. from Nextbiotics Inc. in Scientific Reports. Have fun! This episode was generated using artificial intelligence. An infectious disease researc…
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Hello and welcome to PhageLine - your line to everything phage. This week, we will focus on 3D models for mimicking biofilms in diabetic foot ulcers for phage therapy. German researchers from Frankfurt and Jena recently reviewed this topic. The phage lab at the University Hospital Frankfurt was recently featured in Capsid & Tail for having built it…
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Hello and welcome to PhageLine - your line to everything phage. This week, we will focus on the mechanisms of tailed bacteriophage adsorption. For that, we will discuss a review from Storms and Sauvageau from the Department of Chemical and Materials Engineering at the University of Alberta, which was published in Elsevier's "Virology" in 2015. Have…
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Welcome to PhageLine. This week, we will focus on the applications of bacteriophage-derived endolysins for foodborne bacterial pathogens and food safety, a topic recently reviewed by Kahn et al. from Shenzhen University in Frontiers of Microbiology. Have fun! #medicine #biology #bacteriophages #infection #amr #basicresearch #food #foodsafety This e…
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Welcome to PhageLine. This week, we will focus on CRISPRi-ART, a method for functional genomics of diverse bacteriophages published by Benjamin Adler et al. from the University of California in Nature Microbiology at the end of February. Have fun! #medicine #biology #bacteriophages #infection #amr #basicresearch #CRISPR #genomics #cas13 This episod…
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Welcome to PhageLine. This week we will examine the synergistic action of mucoactive drugs and phages against Pseudomonas aeruginosa and Klebsiella pneumoniae. Have fun! #medicine #biology #bacteriophages #cough #amb #nac #infection #amr This episode was generated using artificial intelligence. An infectious disease researcher reviewed the contents…
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Welcome to PhageLine. This week we will focus on the molecular basis of foreign DNA recognition by the BREX anti-phage immunity system. Have fun! This episode was generated using artificial intelligence. An infectious disease researcher reviewed the contents of the episode.#medicine #biology #bacteriophages #bacteria #defense #infection #amr…
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Welcome to PhageLine. This week we will focus on a bacteriophage-based method for infection and thrombosis prevention using a phage-immobilized, nitric oxide-releasing surface. Have fun! This episode was generated using artificial intelligence. An infectious disease researcher reviewed the contents of the episode. #medicine #biology #bacteriophages…
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Welcome to PhageLine. This week we will focus on using specific phage proteins called endolysins instead of whole phages to fight bacteria by discussing the in vitro and in vivo efficacy of an engineered endolysin targeting Gram-negative pathogens. Have fun! This episode was generated using artificial intelligence. An infectious disease researcher …
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Welcome to PhageLine. In this week's episode, we will focus on one of the biggest phage papers in 2024: a multicentre, multinational, retrospective observational study of personalized bacteriophage therapy outcomes for 100 consecutive cases headed by Jean-Paul Pirnay and Sarah Djebara. This episode was generated using artificial intelligence. An in…
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If you’re in the field of bacteriophage therapy or looking to break into the space, you won’t want to miss the 7th Bacteriophage Therapy Summit happening next month in Boston! 🌍💡 This is the place to be if you're passionate about combating antibiotic resistance and advancing the next generation of phage-based treatments. 💬 Want to connect with top …
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Welcome to PhageLine. In this week's episode, we will discuss bacteriophage-based biosensor technology by discussing the review Bacteriophage-based biosensors technology: Materials, fabrications, efficiencies and shortcomings (Haq et al., 2025 Biotechnology Reports). This episode was generated using artificial intelligence. An infectious disease re…
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Welcome to PhageLine. In this week's episode, we will discuss the isolation and characterization of phages with clinical relevance from environmental sources. This week's papers are: Isolation of a lytic bacteriophage against extensively drug-resistant Acinetobacter baumannii infections and its dramatic effect in rat model of burn infection (Ghazna…
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Hello and welcome to PhageLine - your line to everything phage. This podcast is where we discuss exciting research papers on bacteriophages once a week. To get started let's get a general overview of the topic by talking through a review by Kortright et al. from 2019 (last author Paul E. Turner), titled "Phage Therapy: A Renewed Approach to Combat …
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Understanding Phage Therapy from a General Public's Perspective with Dr. Christopher Shaffer
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Happy Tuesday Everyone and Welcome back to the latest episode of Phage Therapy Today! Phage science is awesome, the business is growing, and the numbers on paper are looking great. But along with this excitement, we must realize the end goal is to save lives and improve clinical outcomes. The truth is phage therapy is still very far from accessible…
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Global Funding Opportunity at INCATE with Dr. Mercedes Gonzalez and Kinzbio CEO Dr. Gregorio Iraola
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Welcome back to Phage Therapy Today! As phage therapy is becoming global, so are funding opportunities. In this week's episode, our guests, Dr. Mercedes Gonzalez from Incubator for Antibacterial Therapies in Europe (INCATE) and Dr. Gregorio Iraola, at Kinzbio sat down with us to talk about these funding opportunities and how startup companies can b…
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Good Manufacturing Practices (GMP) in Phage Therapy with Dr. Frenk Smrekar, founder and CEO at JAFRAL
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Standardizing the phage therapy industry through processes like clinical trails is the way to go . One of the fundamental steps to broader use of phage therapy and successful therapy is producing phages following Good Manufacturing Practices (GMP) and JAFRAL is the leader in this field. In today's show we sit down with JAFRAL's founder and CEO Dr. …
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As a serial entrepreneur, Johan Wikstroem founded a phage therapy company recently with one goal in mind, to treat his own Mycobacteroides abscessus infection and more people with conditions like himself. Listen in to this week's "Phage Therapy Today" and find out more about how our guest transitioned from tech to biotech and overcoming the hurdles…
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A Phage Therapy Cardiology Patient Case Study and Followup with Dr. Gina Suh: Director at Mayo Clinic's Phage Therapy Program
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In this week's Phage Therapy Today, we get back together with Dr. Gina Suh to learn about her recent progress and experience in the application of phage therapy at Mayo Clinic. If you are interested in learning about the first case of phage therapy in treatment of a cardiology case, leading to a successful heart transplant after the clearing of hea…
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Bacteriophage Drug Development and Regulatory Affairs with Dr. Carrie-Lynn Langlais Furr, CEO and Co-founder at Bacteriophage & Drug Development Consultants (BDDC)
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As more phage-based and phage-derived products and therapies emerge, swift decisions and strategies in drug development, designing clinical trials and approaching regulatory agencies come in handy. In this week's Phage Therapy Today, we sit down with Dr. Carrie-Lynn Langlais Furr, coming from a solid bacteriophage science background and coming with…
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Happy Tuesday everyone and welcome back to phage therapy today! Listen in to today's episode, we sit down with Dr. Ben Temperton, Professor at University of Exeter and founder of Citizen Phage Library. Learn about Dr. Temperton's journey and his vision for how citizen phage library can help shape the phage therapy landscape. Let's give it a listen!…
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Bacteriophage Engineering for Clinical and Agricultural Applications with Cytophage Technologies Inc. CEO Dr. Steven Theriault
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Phage killing bacteria is cool but understanding phages and engineering their molecular biology is just another level cool. In today's 'Phage Therapy Today' podcast, we sit down with Dr. Steven Theriault, a proud Canadian, a scientist, and an entrepreneur from Cytophage Tehnologies Inc. Listen to the episode and learn about how he is building and e…
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Phage genome annotation is a critical component in phage therapy to help us understand the functions of phage genes and ensure efficacy of phages. In this week's phage therapy today, we sit down with the founder and CEO at Rime Bioinformatics Dr. Antoine Culot to discuss the current challenges, regulations and opportunities in using bioinformatic t…
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"The Genesis Story" and Progress in Phage Therapy with Dr. Steffanie Strathdee at UCSD IPATH
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In today's show, we sit down with Dr. Steffanie Strathdee, whose family story of saving her husband's life from a life-threatening superbug infection using phage therapy really inspired a lot of the most important works today in the phage therapy field. Listen to today's episode to learn about her story. Among her many roles, as the director of the…
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Using bacteriophages to bring back antimicrobials sensitivity in Acinetobacter baumannii with Dr. Jeremy Barr
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How do bacteriophages shape bacterial fitness and how does it lead to the resensitiization of antimicrobials? In today's show, we are delighted to have Dr. Jeremy Barr from Monash University to talk about his research and his recent republication on Nature Microbiology "Bacteriophage-resistant Acinetobacter baumannii are resensitized to antimicrobi…
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There have been several quite famous successful cases of using phage therapy for treatment. One of those cases was carried out at Mayo Clinic by the founder and director of Mayo Clinic’s Phage Therapy Program Dr. Gina Suh. Listen to our conversation on this story and the consideration along the process. We dig deep into how physicians are perceivin…
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Entrepreneurship in Phage Therapy and Fighting Cholera, Poverty, Social Injustice and so much more with Dr. Minmin Yen @PhagePro
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Welcome back to Phage Therapy Today and in this episode, we have Dr. Minmin Yen from PhagePro joining us to discuss her and her team's recent progress on bringing preventive phage therapy product to fight Cholera, an acute, diarrheal illness that's often associated with poverty, poor infrastructure and social injustice. Listen to her journey of bri…
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Combating Antibiotic-Resistant Bacteria Biopharmaceutical Accelerator(CARB-X) is one global nonprofit partnership that manages a large portfolio of early stage companies to do the job as described by its name. In this episode, we are happy to have its chief scientist Dr. Richard Alm to help us paint a broad picture of the antimicrobial landscape an…
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Interacting with the FDA: A Dynamic Process, an interview with Dr. Austen Terwilliger @BMC TailorLabs
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Dr. Austen Terwilliger is the director of operations at BMC TailorLabs, overseeing the cooperation between phage providers, physicians and regulatory agencies. In this conversation, we sit down and understand the dynamic nature in these processes and let's take a minute to think about how we can setup standards to better help patients. Check out Dr…
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In business for just 5 years, Adaptive Phage Therapeutics has no doubt made tremendous progress and built itself as one of the most competitive leader in our industry. Learn about the founding story and the milestones achieved at APT from its CEO Greg Merril, and most importantly, the direction Greg envisions where we are going. Attached here is th…
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Phage Exploration and Phage Therapy @BCM TailorLabs with Dr. Sabrina Green: Phages, from Bench to Bedside
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We may think the magic in phage therapy is in the treatment. That is true. But to make this magic happen, collaborative team efforts is necessary to together prepare the stage and get ready for the show. Dr. Sabrina Green is currently the director of R&D at Baylor college of medicine Tailorlabs 'https://www.bcm.edu/research/research-centers/tailor'…
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