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Curbside Consults take a deep dive into key topics with expert clinicians and educators. As we explore the details of pathophysiology and critique the evidence behind clinical practice, these conversations are intended to give you better understanding of the topic and greater confidence when treating your patients.
 
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A VIDEO RECORDING OF THIS INTERVIEW IS AVAILABLE HERE. We’re back with another interview from this year’s IASLC conference. This time, Christine Sadlowski and Dr. Julia Rotow interview Dr. Mariano Provencio about the survival outcomes from the NADIM II trial. In that trial, patients with resectable stage III AB non-small cell lung cancer received n…
 
Featuring articles on redirecting T cells against myeloma cells, the removal of small kidney stones and relapse, the treatment of severe alpha1-antitrypsin deficiency, and BNT162b2 protection against omicron in children; a review article on bronchiectasis; a case report of a man with perianal and penile ulcers, pain, and rash; and Perspective artic…
 
In this episode of Curbside Consults, we examine the latest recommendation statement on the use of aspirin to prevent cardiovascular disease from the United States Preventive Services Task Force (USPSTF). We are joined by Michael Barry, who is Director of the Informed Medical Decisions Program in the Health Decision Sciences Center at...…
 
A VIDEO RECORDING OF THIS INTERVIEW IS AVAILABLE HERE. Interim results on overall survival in phase 3 of the IMpower010 trial were presented at this year’s meeting of the International Assosciation for the Study of Lung Cancer (IASLC). As part of the NEJM Group’s coverage of the conference, Christine Sadlowski interviewed the presenter, Dr. Enrique…
 
Featuring articles on a monoclonal antibody to prevent malaria infection, monoclonal antibody therapy in Parkinson’s disease, and dulaglutide in youths with type 2 diabetes; a review article on spina bifida; a Clinical Problem-Solving on diagnostic aspirations; and Perspective articles on building a national public health system in the U.S., on a p…
 
A VIDEO RECORDING OF THIS INTERVIEW IS AVAILABLE HERE. THE USUAL AUDIO FILE IS AVAILABLE BELOW Steven Cummings has co-written a take-no-prisoners editorial in the New England Journal of Medicine. The topic? Vitamin D supplements. The conclusion? “…providers should stop screening for 25-hydroxyvitamin D levels or recommending vitamin D supplements, …
 
Featuring articles on supplemental vitamin D and incident fractures, brentuximab vedotin in advanced Hodgkin’s lymphoma, litifilimab for cutaneous lupus erythematosus, genetic protection against liver disease, and on lawmakers v. the scientific realities of human reproduction; a review article on tobacco addiction; a case report of a man with hypog…
 
In this episode of Curbside Consults, we are joined by Dr. Clyde Yancy, Chief of Cardiology at the Feinberg School of Medicine, past chair of the American College of Cardiology/American Heart Association Heart Failure Guidelines Committee, and a senior member of the committee that authored the new 2022 Guideline for the Management of...…
 
A VIDEO RECORDING OF THIS ROUNDTABLE IS AVAILABLE CLICK HERE. THE USUAL AUDIO FILE IS AVAILABLE BELOW Your host is old enough to remember when hospital corridors featured physicians with little black bags, scurrying around to see their patients. That’s no longer true, of course. Most of the physicians seen in those corridors these days are white-co…
 
Featuring articles on tirzepatide for weight loss in adults with obesity, pembrolizumab in triple-negative breast cancer, Covid-19 vaccination in children 5 to 11 years of age, and gene therapy for hemophilia B; a review article on obesity in pregnancy; a case report of a woman with cavitary lung lesions; and Perspective articles on communicating s…
 
Featuring articles on maternal vaccination and Covid-19 among infants, adagrasib in KRASG12C-mutated lung cancer, continuous maintenance therapy in myeloma, and erythropoietin for hypoxic–ischemic encephalopathy in newborns; a review article on breakthrough hemolysis after complement inhibition; a case report of a girl with fever and cough; and Per…
 
CREST-2’s results are probably more than a year away. In the meantime, what to do about diagnosed severe (but asymptomatic) carotid stenosis? Recent results suggest that medical management compares favorably with the surgical approach. In this edition, we address the question with a conversation between Dr. Allan Brett, NEJM Journal Watch‘s editor-…
 
Featuring articles on trastuzumab deruxtecan in HER2-low breast cancer, effects of previous infection and vaccination on symptomatic omicron infections, and a report on porcine-to-human cardiac transplantation; review articles on pulmonary embolism and on the vaccine-hesitant moment; a Clinical Problem-Solving on the young and the breathless; and P…
 
The CEO of Blue Cross Blue Shield of Massachusetts describes his work in making population-based contracts a norm in the state and what still needs to be done to improve health care affordability and access.NEJM Group
 
Locally advanced rectal cancer usually receives a three-part treatment: chemotherapy followed by radiotherapy and then surgery. In a small-cohort study presented at this year’s ASCO conference researchers used a PD-1 inhibitor — dostarlimab — every three weeks for 6 months against the disease. All patients had mismatch repair deficient tumors. No o…
 
In this episode of Curbside Consults, we examine the latest guidelines from the Centers for Disease Control (CDC) on the treatment of sexually transmitted infections (STIs). We are joined by Dr. Kimberly Workowski, a Professor of Medicine in the Division of Infectious Diseases at Emory, and one of the guideline authors.…
 
Featuring articles on restricted intravenous fluid in septic shock, an oncolytic virus for pediatric pontine glioma, ibrutinib for untreated mantle-cell lymphoma, and on the potency of a KRAS silent variant; a review article on mantle-cell lymphoma; a case report of a man with vision changes; and Perspective articles on nineteen days in America, on…
 
Patients with metastatic breast cancer whose tumors express low levels of HER2 are generally classified and treated as having HER2-negative disease. However, Dr. Shanu Modi of the Memorial Sloan Kettering Cancer Center and a group of international collaborators explored the use of a monoclonal antibody–drug conjugate (trastuzumab–deruxtecan) in pat…
 
Featuring articles on PD-1 blockade in locally advanced rectal cancer, a vaccine against respiratory syncytial virus, a vitamin C infusion in adults with sepsis, and reducing administrative harm in medicine; a review article on Philadelphia chromosome–positive acute lymphoblastic leukemia; a case report of a woman with jaundice and chronic diarrhea…
 
Apnea testing is part of the protocol used to determine whether a patient is dead according to neurologic criteria. The question is, do clinicians need to obtain consent to proceed? In a fascinating 15-minute chat, two intensivists, Drs. Patricia Kritek and Robert Truog, discuss that question and another, larger one: what is death, anyway? Their ba…
 
Featuring articles on circulating tumor DNA and adjuvant therapy in colon cancer, the prevention of anal cancer, Chapare hemorrhagic fever in Bolivia, immune tolerance after sequential stem-cell and kidney transplantation, and potentiating the T cell; a review article on climate change, fossil-fuel pollution, and children’s health; a case report of…
 
In this episode of Curbside Consults, we discuss the intersection of climate change, health, and education with a group of residents and medical students who are leading initiatives to incorporate climate change into the curriculum at institutions across the country. We are joined by Dr. Jacob Fox, second year internal medicine resident at...…
 
As Editor-In-Chief of the New England Journal of Medicine, Dr. Eric Rubin is an authority on medical publishing, but he didn’t always know this was the job he wanted. In this special episode of Curbside Consults, we explore the highlights and challenges of being a physician editor at a medical journal, and the path to determining if it’s the right …
 
Featuring articles on chronic traumatic encephalopathy in military personnel, a PDE4 inhibitor for idiopathic pulmonary fibrosis, a monoclonal-antibody combination to prevent Covid-19, natural and hybrid immunity to SARS-CoV-2, and emerging technologies in health and medicine; a review article on the diagnosis and treatment of frostbite; a case rep…
 
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