Кращі подкасти про Bitesize Bio (2024)

1
Unleash New Biological Insights with Innovative Glycoanalytics 53:21

1d ago53:21

53:21

Glycosylation is a prevalent modification of proteins known to play diverse roles across a wide range of biological processes. While glycoproteins are widely recognized as key molecular features involved in human health and disease, the analysis of protein glycosylation has historically been hampered by a lack of efficient and simple methods to cha…

1
Contamination and Recovery of PFAS in Analytical Methods Requiring Filter Membranes 49:51

8d ago49:51

49:51

Liquid chromatography-mass spectrometry (LC-MS) is a crucial technique in many life sciences, including proteomics, metabolomics, pharmaceutical analysis, clinical diagnosis, and forensic science. In this episode of Listen In, elevate your analysis and liquid chromatography. Learn what consumables, materials, and reagents can harm your LC-MS data f…

1
Biology Bites | Episode 1: Introducing Benjamin Margate & Online Biology Tutors 9:10

9d ago9:10

9:10

Dive into the dynamic world of biology with Benjamin Margate, biologist, tutor, and proud to announce himself as the owner of Online Biology Tutors, on Biology Bites. Each episode unpacks the complexities of biology, offering accessible, in-depth discussions designed to ignite passion and enhance understanding. This week, join Benjamin as he unveil…

1
Label-free 3D Live Cell Imaging and Quantification using Holotomography 1:02:03

15d ago1:02:03

1:02:03

Holotomography has emerged as a helpful tool for imaging live specimens without additional pre-treatment, such as fixation, fluorescence labeling, and excitation. It can achieve long-term three-dimensional observations of live specimens for weeks without cellular damage caused by photoactivation. The high resolution (under 150 nm lateral) achieved …

1
Back to Buffer Basics: Everything You Need to Know About Buffers 57:09

22d ago57:09

57:09

Buffers are critical to nearly all our experiments. Poorly prepared buffers lead to failed Western blots, poor protein yields, flat binding curves—and wasted time. Understanding why you need buffers, knowing how to choose the right one, and troubleshooting buffer issues are fundamental skills you can apply to make all your experiments work better—a…

1
How to Write a Research Paper IV: Understanding the Publication Process 49:24

29d ago49:24

49:24

You have written a research paper. What now? Your research can only have an impact if someone reads it. So, you must submit your article to a journal for publication. In this episode of Listen In, learn the nuts and bolts of scientific publication with a step-by-step tour of the whole process. Explore how to select the right journal and what tools …

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How to Write a Research Paper III: Common Problems and How to Overcome Them 1:01:34

1M ago1:01:34

1:01:34

The best way to solve a problem is to avoid it in the first place. While journals can and do reject articles for scientific reasons, they also reject articles for structural issues. By taking a few simple steps, you can learn how to circumvent these difficulties for a smooth publication process. In this episode of Listen In, we'll go through some o…

1
How to Write a Research Paper II: The Anatomy 1:01:54

1M ago1:01:54

1:01:54

All research papers have certain elements in common: Introduction, Methods, Results, and Conclusion. How can you structure your introduction to best frame the research question for your readers? Must the methods section read like a laundry list of reagents? Can you be dramatic in the results without losing objectivity? Is there any room in the conc…

1
How to Write a Research Paper I: Telling Your Story 1:08:27

2M ago1:08:27

1:08:27

Rarely do we consider writing a scientific paper as a creative exercise. But what if that could change? The best way to communicate anything is through stories. The scientific process has all the elements inherent in storytelling: a rich background, a problem or conflict to solve, and a resolution. In this episode of Listen In, we will reframe the …

1
Using Antisense to Characterize Nonsense: A Mouse Model of Progranulin-Deficient Dementia 42:09

2M ago42:09

42:09

Transgenic mouse models are important tools for testing therapeutic strategies. In this episode of Listen In, discover the benefits and essential considerations when characterizing and using transgenic mouse models to test therapeutic approaches to treat neurodegenerative diseases. Plus, explore a knock-in mouse model of frontotemporal dementia tha…

1
Visualizing Membrane Dynamics by Electron Microscopy 40:30

2M ago40:30

40:30

Explore how the latest electron microscopy techniques and volume imaging can capture fast, dynamic membrane and vesicle remodeling events during synaptic transmission at the ultrastructural level. Neurons communicate at specialized junctions, or synapses, via chemical messengers called neurotransmitters. Within a millisecond of neuronal stimulation…

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Benefits of Imaging Data in Flow Cytometry Experiments: A Panel Discussion 41:43

2M ago41:43

41:43

Experience the transformative power of unbiased, data-driven cell analysis with access to over 25 image-derived label-free parameters, empowering you to easily assess sample quality, optimize gating strategies, and validate rare events. In this episode, learn how automated image analysis combined with flow cytometry can help improve data accuracy a…

1
Jump into 3D Organoids: Basic Culture Techniques and Advanced Applications 1:01:26

3M ago1:01:26

1:01:26

Organoids are three-dimensional in vitro cultures derived directly from patient tissues or induced pluripotent stem cells (iPSC) and embryonic stem cells. They self-organize to generate structures that resemble the tissue of origin and recapitulate the key physiological functions of the parental organ. In this episode of Listen In, explore the bene…

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Ethical Research Practice III: Image Manipulation – What's Ok, and What's Not 59:36

3M ago59:36

59:36

As a scientific researcher, you must present your work in an unbiased, original, and representative way. Without due care and attention, it is easy to drift over the boundary of what is acceptable and slip into habits that are unacceptable within the scientific community. This episode of Listen In with Cristy Gelling explores image manipulation. Ma…

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Ethical Research Practice II: Reporting Negative Results and Outliers 48:41

3M ago48:41

48:41

As a scientific researcher, you must present your work in an unbiased, original, and representative way. Without due care and attention, it is easy to drift over the boundary of what is acceptable and slip into habits that are unacceptable within the scientific community. This episode of Listen In with Karen O'Hanlon Cohrt explores publishing negat…

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Ethical Research Practice I: Plagiarism – What It Is and How to Avoid It 59:54

3M ago59:54

59:54

As a scientific researcher, you must present your work in an unbiased, original, and representative way. Without due care and attention, it is easy to drift over the boundary of what is acceptable and slip into habits that are unacceptable within the scientific community. This episode of Listen In with Karen O'Hanlon Cohrt defines plagiarism and pr…

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Everyday Culture Practice: Improving Reproducibility in Cell Culture 58:41

4M ago58:41

58:41

Eukaryotic cell cultures respond to the slightest influence. Apart from the risk of contamination, minimal changes in cultivation parameters can affect their viability, growth, and cell metabolism. In this episode of Listen In, discover the measures you can take to improve the reproducibility of your experiments by incorporating Good Cell Culture P…

1
Precision and Efficiency at Your Fingertips: Why Electronic Pipettes are the Future of Pipetting 51:52

4M ago51:52

51:52

Many scientists see the added value in using electronic pipettes and have already upgraded their pipette fleet. The benefits include: • Reduced strain on thumbs and arms by improving pipetting ergonomics. • Increased reproducibility of experiments with motor-operated pipetting cycles. • Easy and efficient handling of high sample throughput. In this…

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Introduction to Liquid Handling for Next-generation Sequencing Workflows 1:04:03

5M ago1:04:03

1:04:03

Next-generation sequencing (NGS) has revolutionized the ‘omics’ era, with the rapid decoding of massive DNA sequences, supporting the investigation into various biological processes in human disease, genetic inheritance, immunity, cancer, and others. But generating high-quality NGS libraries is a labor-intensive process that requires experience, pr…

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Essentials in Centrifugation—Better Safe than Sorry! 1:03:10

5M ago1:03:10

1:03:10

Centrifugation is the cornerstone of lab life, used in nearly every workflow, be it a routine task like pelleting cells or a dedicated assay for an important biomolecular target. That's why it's such a pain when they break down. But just because we use centrifuges every day doesn't mean there aren't important technical aspects to consider or no par…

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Ten Common Statistical Mistakes to Watch out for When Writing or Reviewing a Manuscript 51:32

6M ago51:32

51:32

Some scientific papers are unbelievable as they showcase experimental excellence that we did not think possible. These papers astound us with their groundbreaking findings and meticulous methodologies. However, alongside these unbelievably good papers, there are papers that are unbelievable due to the pervasive presence of statistical mistakes that…

1
How to Keep Your ULT Freezer Healthy 51:17

6M ago51:17

51:17

Your ultra-low temperature (ULT) freezer is not just a storage room for samples; it is your assurance for long-term scientific success and guards the results of your work. Therefore, every researcher should understand the importance of ULT freezers, know how to choose a reliable one, understand best practices for sample management, and have clear g…

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Reproducibility: Mastering the Art of Pipetting 1:24:10

7M ago1:24:10

1:24:10

Have you ever transferred glycerol or ethanol with a pipette? We all know how hard it is, and we've all been dubious about the accuracy of our final volumes. While you probably realize that your liquid type and pipetting technique can influence your analysis results, you might be less sure about what pipettes to use when your assays involve challen…

1
Real-time IntraVital Microscopy (IVM): In Vivo Cellular-level Imaging of Internal Organs in a Live Animal 1:02:55

8M ago1:02:55

1:02:55

Intravital imaging of cellular dynamics in a natural physiological microenvironment can provide unprecedented insights into the dynamic pathophysiology of diseases. In this episode of Listen In, get a demonstration of the latest technology to image inside the cells of live animals. Watch real-time multicolor sub-micron resolution image acquisition …

1
Errors and Misconduct in Biomedical Research 1:03:32

8M ago1:03:32

1:03:32

What are the motives behind science misconduct? How is data manipulated to evidence dubious results? And do you think you can spot edited and faked data? Any fraud in science is too much, but the reasons for it are complex. In this episode of Listen In, join forensics detective Elisabeth Bik and explore the answers to these questions. See the work …

1
Garbage In, Garbage Out: Sample Prep for Flow Cytometry 1:00:44

8M ago1:00:44

1:00:44

What's more disappointing than running your flow cytometry sample to discover it's rubbish? Especially considering time on cytometers can be precious, even more so if you've booked onto an in-demand one at a busy core facility. You've done all the work and all the waiting—for nothing. If this scenario sounds familiar, this episode of Listen In is f…

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Consistent, Error-Free Writing: Tips and Tricks for Time-starved Scientists 49:24

9M ago49:24

49:24

Scientific writing is an art that requires as much attention and proficiency as your hands-on lab work. When done right, it can significantly contribute to your scientific endeavors. But, if not taken seriously, inconsistent language, formatting, and terminology can hinder your work's clarity and distract from your remarkable scientific findings. I…

1
Lab Meetings Live: Career Paths for Bioscientists 1:03:57

9M ago1:03:57

1:03:57

Are you an early career scientist looking for guidance on your career path? Or you're a seasoned researcher considering a career change and want to know what's out there. We've brought together a panel of experts and bioscientists with a wide range of experience to share their insights and help you carve out the best career possible. Get advice and…

1
Breaking the Ice: Freeze Fracture for Cryo SEM 1:16:16

10M ago1:16:16

1:16:16

Freeze fracture is a powerful technique that enables imaging of internal structures of cells and tissues at the nanoscale level by freezing samples at ultra-low temperatures and then fracturing them along natural weak points. These structures can be imaged without dehydration or distortion using cryo-SEM, providing high-resolution images with great…

1
Practical Examples of Critical Analysis of Manuscripts 42:22

10M ago42:22

42:22

As a researcher, one of the most crucial skills to develop is the ability to perform a thorough review of manuscripts. Manuscript reviewing is a vital job that requires specific skills and knowledge to properly assess published literature. By reading and reviewing papers, researchers can develop and hone these skills, which will help them identify …

1
Using Both the Right and Left Parts of Your Brain to Get the Perfect Job 46:10

11M ago46:10

46:10

Have you ever wondered what other jobs are ideal matches for your analytic and artistic skills? Are you looking for an exciting new career in marketing, or have you ever wondered if it was for you? In this episode of Listen In, discover how the assets that make you a great scientist could also make you a great marketer in today's data-driven market…

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How to Prepare a Winning Grant Proposal – Part 3: Resubmission 44:26

11M ago44:26

44:26

In the third part of our grant writing tutorial series, you’ll learn how to process a grant review and take the next steps. Dr. Seigel shares how to read and interpret a summary statement, ways to address critiques, and when you shouldn't resubmit. You'll hear real-world examples from previous grants to give you a flavor of what you can expect. Wat…

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How to Prepare a Winning Grant Proposal – Part 2: Nuts and Bolts 47:38

11M ago47:38

47:38

In the second part of our grant writing tutorial series, you’ll learn how to get the attention and respect of the reviewers by presenting your ideas in the best possible light. Dr. Seigel shares essential elements of writing the research plan section of your proposal, such as the essential items to include in your research plan, how to write a comp…

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How to Prepare a Winning Grant Proposal – Part 1: Getting Started 1:02:34

11M ago1:02:34

1:02:34

Writing grant proposals can be daunting, especially when the stakes are high. Getting started is the first and potentially hardest step to writing a proposal that gets you funded. Join Dr. Gail Seigel, a highly experienced faculty member with over 25 years of grant-writing and grant-reviewing expertise, as she shares her wisdom on kickstarting the …

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The Reproducibility Crisis: Why? How? What Now? 56:29

12M ago56:29

56:29

Reproducibility is a cornerstone of the scientific technique, and something that is not reproducible is unlikely to be true. Yet despite its frequent neglect, reproducibility is fundamental. It enables scientists to continue and expand upon existing work and builds trust in science and the scientific method. So in what ways does the so-called repro…

1
How To Critically Analyze A Research Paper 40:41

12M ago40:41

40:41

Don't sabotage your work by missing critical details. Let's face it; research papers are a pain to read. Their dry language and sheer density make crucial details hard to spot and obscure salient findings. And if we're being honest, not every researcher is equally scrupulous. Sifting through mountains of papers to find the hidden gem that fills in …

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The Art of Going Slow: Why Scientists Need to Slow Down 1:06:20

12M ago1:06:20

1:06:20

Deadlines. Results. Presentations. Publications. Scientists are under a lot of pressure. And many of us have had our working lives changed by recent global events in ways that have separated us from our colleagues and normal working routines. Many of us feel strained and under pressure to maintain our productivity despite these changes. But how? Th…

1
Top tips for writing a research poster 1:21:34

1y ago1:21:34

1:21:34

Are you excited, nervous, or perhaps terrified about presenting a poster for an upcoming conference? Poster sessions can be daunting, no matter if this is your first poster experience or if you've done them before. Poster sessions are an amazing opportunity to get feedback on your research, make vital connections with others in your field, and hone…

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Writing for the Web—Tips and Advice for Scientists 47:11

1y ago47:11

47:11

Are you looking to share your science online with a broader audience? Or maybe you are considering a career shift and want to move into science writing. There are many reasons you might want to start writing content online. While you may have experience writing papers, grants, and other content, writing specifically for the web requires different c…

1
Grammar 101 for Scientists 1:22:44

1y ago1:22:44

1:22:44

We all dread the feedback on our written work, but it doesn't have to be so daunting! Join the Bitesize Bio editorial team for a fun and friendly introduction to grammar for scientists, as we cover everything from punctuation to the passive voice. We'll talk you through some of the most common grammar pitfalls in science writing and show you how to…

1
What is science writing? A guide for researchers considering a career change 1:02:10

1y ago1:02:10

1:02:10

Are you a scientist looking for a change of pace? Have you ever considered using your scientific knowledge and communication skills to become a science writer or communicator? Well, look no further! In this exciting episode of Listen In, we take you on a journey exploring the many different avenues of science writing—from technical medical writing …

1
5 Principles for Creating a Rewarding Career Inside or Outside of the Lab 1:01:54

1y ago1:01:54

1:01:54

Only a tiny percentage of bioscience PhD students will progress to a PI position. This statistic means that ~95% of us need to find a career path other than the traditional academic one most of us aim for when we set out as scientists. Listen in to hear from Bitesize Bio's founder, Dr. Nick Oswald, and discover five simple but powerful principles y…

1
Precise, high-efficiency editing of stem cells to probe human biology and model disease 50:30

1y ago50:30

50:30

Discover how combining two nobel-prize winning technologies—cell reprogramming and CRISPR gene editing—creates a powerful platform to study basic cell biology, development, and disease. You'll learn how this technology overcomes problems with more traditional immortalized cell models and see how it is already being used to study neurodegenerative d…

1
Base editing in practice 1:07:59

1y ago1:07:59

1:07:59

Base editing allows researchers to make precise changes to the genome. Discover how this technique works, how it differs from traditional genome editing, and how it is being used to understand human variation. This webinar is presented by Alexis Komor, Assistant Professor at The University of California, San Diego. Follow Alexis and The University …

1
CRISPRi as an alternative to CRISPR-cut in human iPSCs 22:29

1y ago22:29

22:29

Get help and advice with designing and using CRISPRi in human iPSCs. Discover that CRISPRi is an efficient way to silence transcription, sometimes in a complete manner, with loss of H3K4me3 activation marks. Learn how to eliminate side effects of clonal expansion and sites of viral vector integration by using a method that avoids single-cell select…

1
The 4 D’s of CRISPR gene editing: Design, Develop, Deliver and Detect 59:46

1y ago59:46

59:46

Whether you are just getting started with CRISPR or want to refresh the basics in designing and performing CRISPR experiments, Dr. Antony Adamson can help. [1] As Manager of the Genome Editing Unit at the University of Manchester, [2] he's helped numerous researchers achieve their varied CRISPR goals. Tap into his knowledge and wisdom in this enlig…

1
The World of Macrophages: How to Harness Them for Research 1:00:20

1+ y ago1:00:20

1:00:20

Although macrophages were first described by Elie Metchnikoff in 1882, plenty of mysteries are still associated with the cell type. Indeed, while macrophages were once considered simply “garbage trucks” of the immune system due to their phagocytic property, their substantial and multifaceted contribution to immunological responses and homeostasis i…

1
Basics of FLIM and Applications to FRET Biosensors 51:05

1+ y ago51:05

51:05

Functional imaging is a rapidly growing field key to driving new understanding in biology. Insights into the function and interaction of molecules are the key to reveal the underlying cellular mechanisms. In this context, fluorescence lifetime imaging (FLIM) is a powerful tool, providing valuable information beyond spectral imaging. FLIM is immune …

1
Adding Multiplex Factor to Confocal Imaging with ZEISS LSM 49:08

1+ y ago49:08

49:08

In this tutorial on confocal imaging, you will learn how you can: – Capture weaker signals—and still get sound, reproducible data. – Reach faster volumetric imaging without sacrificing resolution – Increase data throughput for your imaging needs Learn about the new Multiplex mode for parallel pixel acquisition with the ZEISS LSM 9 family and Airysc…

1
Cryo-electron Tomography for Cell Biology 59:51

1+ y ago59:51

59:51

In this webinar, you will learn: – The complete workflow for in situ cryo-electron tomography – How subtomogram averaging within the cell yields native-state structures of macromolecular complexes (e.g., the asymmetric and dilated nuclear pore of algae) – How mapping these structures back into the native cellular environment reveals new molecular i…

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